ID A0A2R9AVU0_PANPA Unreviewed; 216 AA.
AC A0A2R9AVU0;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Kv channel-interacting protein 4 {ECO:0000256|ARBA:ARBA00040738};
GN Name=KCNIP4 {ECO:0000313|Ensembl:ENSPPAP00000021308.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000021308.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000021308.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000021308.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}.
CC -!- SIMILARITY: Belongs to the recoverin family.
CC {ECO:0000256|ARBA:ARBA00006049}.
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DR EMBL; AJFE02094048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02094049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02094050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02094051; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02094052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02094053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02094054; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02094055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02094056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02094057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008950411.1; XM_008952163.1.
DR AlphaFoldDB; A0A2R9AVU0; -.
DR SMR; A0A2R9AVU0; -.
DR Ensembl; ENSPPAT00000044110.1; ENSPPAP00000021308.1; ENSPPAG00000033844.1.
DR GeneTree; ENSGT00940000158985; -.
DR OrthoDB; 339700at2759; -.
DR Proteomes; UP000240080; Chromosome 4.
DR Bgee; ENSPPAG00000033844; Expressed in cerebellum and 3 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR028846; Recoverin.
DR PANTHER; PTHR23055; CALCIUM BINDING PROTEINS; 1.
DR PANTHER; PTHR23055:SF30; KV CHANNEL-INTERACTING PROTEIN 4; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR PRINTS; PR00450; RECOVERIN.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 3.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 86..121
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 122..157
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 170..205
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 216 AA; 25008 MW; 17C4AFD3B4CFF23C CRC64;
MNVRRVESIS AQLEEASSTG DSVEDELEMA TVRHRPEALE LLEAQSKFTK KELQILYRGF
KNECPSGVVN EETFKEIYSQ FFPQGDSTTY AHFLFNAFDT DHNGAVSFED FIKGLSILLR
GTVQEKLNWA FNLYDINKDG YITKEEMLDI MKAIYDMMGK CTYPVLKEDA PRQHVETFFQ
KMDKNKDGVV TIDEFIESCQ KDENIMRSMQ LFENVI
//
