ID A0A2R9AVU5_PANPA Unreviewed; 1174 AA.
AC A0A2R9AVU5;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=CASK interacting protein 2 {ECO:0000313|Ensembl:ENSPPAP00000021313.1};
GN Name=CASKIN2 {ECO:0000313|Ensembl:ENSPPAP00000021313.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000021313.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000021313.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000021313.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AJFE02042240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9AVU5; -.
DR STRING; 9597.ENSPPAP00000021313; -.
DR Ensembl; ENSPPAT00000044114.1; ENSPPAP00000021313.1; ENSPPAG00000033859.1.
DR GeneTree; ENSGT00940000158256; -.
DR OMA; PRCKERE; -.
DR Proteomes; UP000240080; Chromosome 17.
DR Bgee; ENSPPAG00000033859; Expressed in adult mammalian kidney and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd09497; SAM_caskin1_2_repeat1; 1.
DR CDD; cd09498; SAM_caskin1_2_repeat2; 1.
DR CDD; cd12063; SH3_Caskin2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR033635; ANKS1/Caskin.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032232; Caskin1-CID.
DR InterPro; IPR035497; Caskin1/2_SAM_1.
DR InterPro; IPR035498; Caskin1/2_SAM_2.
DR InterPro; IPR035499; Caskin2_SH3.
DR InterPro; IPR032117; Caskin_C.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24174; ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR24174:SF18; CASKIN-2; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF16907; Caskin-Pro-rich; 1.
DR Pfam; PF16632; Caskin-tail; 1.
DR Pfam; PF16600; Caskin1-CID; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REPEAT 48..80
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 165..197
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 197..229
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 258..324
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 466..529
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 535..599
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 332..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1088..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..358
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..764
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..972
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1040
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1094..1108
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1174 AA; 123837 MW; 48CF1C9CA2D1B8EF CRC64;
MGREQDLILA VKNGDVTGVQ KLVAKVKATK TKLLGSTKRL NVNYQDADGF SALHHAALGG
SLELIALLLE AQATVDIKDS NGETPMCPRP PPWAGRGPTQ TLGPELAPMT TYISPTHAWS
TRPRRRSQEE ALTGHWVLQV AQLLLNSHLC VALLEGEAKD PCDPNYTTPL HLAAKNGHRE
VIRQLLRAGI EINRQTKTGT ALHEAALYGK TEVVRLLLEG GVDVNIRNTY NQTALDIVNQ
FTTSQASREI KQLLREASGI LKVRALKDFW NLHDPTALNV RAGDVITVLE QHPDGRWKGH
IHESQRGTDR IGYFPPGIVE VVSKRVGIPA ARLPSAPTPL RPGFSRTPQP PAEEPPHPLT
YSQLPRVGLS PDSPAGDRNS VGSEGSVGSI RSAGSGQSSE GTNGHGPGLL IENAQPLPSA
GEDQVLPGLH PPSLADNLSH RPLANCRSGE QIFTQDVRPE QLLEGKDAQA IHNWLSEFQL
EGYTAHFLQA GYDVPTISRM TPEDLTAIGV TKPGHRKKIA SEIAQLSIAE WLPSYIPTDL
LEWLCALGLP QYHKQLVSSG YDSMGLVADL TWEELQEIGV NKLGHQKKLM LGVKRLAELR
RGLLQGEALS EGGRRLAKGP ELMAIEGLEN GEGPATAGPR LLTFQGSELS PELQAAMAGG
GPEPLPLPPA RSPSQESIGA RSRGSGHSQE QPAPQPSAPP QERNLPEGTE RPPKLCSSLP
GQGPPPYVFM YPQGSPSSPA PGPPPGAPWA FSYLAGPPAT PPDPPRPKRR SHSLSRPGPT
EGDAEGEAEG PVGSTLGSYA TLTRRPGRSA LVRTSPSVTP TPARGTPRSQ SFALRARRKG
PRPAPKRLSS VSGPSPEPPP LDGSPGPKEG ATGPRRRTLS EPAGPSEPPG PPAPAGPASD
TEEEEPGPEG TPPSRGSSGE GLPFAEEGNL TIKQRPKPAG PPPRETPVPP GLDFNLTESD
TVKRRPKCRE REPLQTALLA FGVASATPGP AAPLPSPTPG ESPPASSLPQ PEPSSLPAQG
VPTPLAPSPA MQPPVLPCPG PGLESSAASR WNGETEPPAA PAALLKVPGA GTAPKPVSVA
CTQLAFSGPK LAPRLGPRPV PPPRPESTGT VGPGQAQQRL EQTSSSLAAA LRAAEKSIGT
KEQEGTPSAS TKHILDDIST MFDALADQLD AMLD
//
