ID A0A2R9AVV0_PANPA Unreviewed; 350 AA.
AC A0A2R9AVV0;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000019920.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000019920.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000019920.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
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DR EMBL; AJFE02011947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02011948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9AVV0; -.
DR Ensembl; ENSPPAT00000042700.1; ENSPPAP00000019920.1; ENSPPAG00000033174.1.
DR GeneTree; ENSGT00940000158599; -.
DR OMA; RLELWVP; -.
DR Proteomes; UP000240080; Chromosome 17.
DR Bgee; ENSPPAG00000033174; Expressed in adult mammalian kidney and 1 other cell type or tissue.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd19354; Wnt_Wnt9b; 1.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027:SF84; PROTEIN WNT-9B; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
SQ SEQUENCE 350 AA; 38469 MW; DD3FB9CBA5BA1305 CRC64;
QPPPPELKLT RLPPLALSSL TGREVLTPFP GLGTAAAPAQ GGAHLKQCDL LKLSRRQKQL
CRREPGLAET LRDAAHLGLL ECQFQFRHER WNCSLEGRTG LLKRGFKETA FLYAVSSAAL
THTLARACSA GRMERCTCDD SPGLESRQAW QWGVCGDNLK YSTKFLSNFL GSKRGNKDLR
ARADAHNTHV GIKAVKSGLR TTCKCHGVSG SCAVRTCWKQ LSPFRETGQV LKLRYDSAVK
VSSATNEALG RLELWAPARQ GSLTKGLAPR SGDLVYMEDS PSFCRPSKYS PGTAGRVCSR
EASCSSLCCG RGYDTQSRLV AFSCHCQVQW CCYVECQQCV QEELVYTCKH
//
