ID A0A2R9AW90_PANPA Unreviewed; 591 AA.
AC A0A2R9AW90;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Myelin transcription factor 1 {ECO:0000313|Ensembl:ENSPPAP00000019244.1};
GN Name=MYT1 {ECO:0000313|Ensembl:ENSPPAP00000019244.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000019244.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000019244.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000019244.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MYT1 family.
CC {ECO:0000256|ARBA:ARBA00010194}.
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DR EMBL; AJFE02030852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9AW90; -.
DR Ensembl; ENSPPAT00000042000.1; ENSPPAP00000019244.1; ENSPPAG00000032781.1.
DR GeneTree; ENSGT00940000156364; -.
DR Proteomes; UP000240080; Chromosome 20.
DR Bgee; ENSPPAG00000032781; Expressed in cerebellum and 2 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 4.10.320.30; -; 5.
DR InterPro; IPR013681; Myelin_TF.
DR InterPro; IPR002515; Znf_C2H2C.
DR InterPro; IPR036060; Znf_C2H2C_sf.
DR PANTHER; PTHR10816:SF10; MYELIN TRANSCRIPTION FACTOR 1; 1.
DR PANTHER; PTHR10816; MYELIN TRANSCRIPTION FACTOR 1-RELATED; 1.
DR Pfam; PF08474; MYT1; 2.
DR Pfam; PF01530; zf-C2HC; 5.
DR SUPFAM; SSF103637; CCHHC domain; 5.
DR PROSITE; PS51802; ZF_CCHHC; 4.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01143}.
FT DOMAIN 262..317
FT /note="Myelin transcription factor 1"
FT /evidence="ECO:0000259|Pfam:PF08474"
FT DOMAIN 319..492
FT /note="Myelin transcription factor 1"
FT /evidence="ECO:0000259|Pfam:PF08474"
FT REGION 1..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 591 AA; 64619 MW; 8487376DA0F0ED3C CRC64;
MSLENEDKRA RTRSKALRGP PETTAADLSC PTPGCTGSGH VRGKYSRHRS LQSCPLAKKR
KLEGAEAEHL VSKRKSHPLK LALDEGYGVD SDGSEDTEVK DASVSDESEG TLEGAEAETS
GQDEIHRPET AEDPSRAEKR EIKCPTPGCD GTGHVTGLYP HHRSLSGCPH KDRIPPEILA
MHENVLKCPT PGCTGQGHVN SNRNTHRSLS GCPIAAAEKL AKSHEKQQPQ TGDPSKSSSN
SDRILRPMCF VKQLEVPPYG SYRPNVAPAT PRANLAKELE KFSKVTFDYA SFDAQVFGKR
MLAPKIQTSE TSPKAFQCFD YSQDAEAAHM AATAILNLST RCWEMPENLS TKPQDLPSKS
VDIEVDENGT LDLSMHKHRK RENAFPSSSS CSSSPGVKSP DASQRHSSTS APSSSMTSPQ
SSQASRQDEW DRPLDYTKPS RLREEEPEES EPAAHSFASS EADDQEVSEE NFEERKYPGE
VTLTNFKLKF LSKDIKKELL TCPTPGCDGS GHITGNYASH RRCPTPGCDG SGHITGNYAS
HRSLSGCPRA KKSGVKVAPT KDDKEDPELM KYVGPCWLFH CIVELRFSCV L
//
