UniProt: A0A2R9AYC7

Database: UniProt
Entry: A0A2R9AYC7_PANPA

LinkDB:  A0A2R9AYC7_PANPA 
Original site:  A0A2R9AYC7_PANPA

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Ontology (8)   
   GO (8)   
Gene (3)   
   ENSEMBL-UP (3)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (39)   
   InterPro (19)   
   Pfam (10)   
   PROSITE (4)   
   SMART (6)   
Literature (1)   
   PubMed (1)   
All databases (52)   

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ID   A0A2R9AYC7_PANPA        Unreviewed;      1725 AA.
AC   A0A2R9AYC7;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPAP00000020054.1};
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000020054.1, ECO:0000313|Proteomes:UP000240080};
RN   [1] {ECO:0000313|Ensembl:ENSPPAP00000020054.1, ECO:0000313|Proteomes:UP000240080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22722832; DOI=10.1038/nature11128;
RA   Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA   Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA   Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA   Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA   Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA   Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA   Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA   Paabo S.;
RT   "The bonobo genome compared with the chimpanzee and human genomes.";
RL   Nature 486:527-531(2012).
RN   [2] {ECO:0000313|Ensembl:ENSPPAP00000020054.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, axon
CC       {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendrite
CC       {ECO:0000256|ARBA:ARBA00004279}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}. Synapse
CC       {ECO:0000256|ARBA:ARBA00034103}.
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DR   EMBL; AJFE02111595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9597.ENSPPAP00000020054; -.
DR   Ensembl; ENSPPAT00000042839.1; ENSPPAP00000020054.1; ENSPPAG00000032907.1.
DR   GeneTree; ENSGT00940000155739; -.
DR   Proteomes; UP000240080; Chromosome 6.
DR   Bgee; ENSPPAG00000032907; Expressed in liver and 6 other cell types or tissues.
DR   GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR   GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   CDD; cd00017; ANATO; 1.
DR   CDD; cd02896; complement_C3_C4_C5; 1.
DR   CDD; cd03584; NTR_complement_C4; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.40.50.120; -; 1.
DR   Gene3D; 2.60.120.1540; -; 1.
DR   Gene3D; 2.60.40.1930; -; 3.
DR   Gene3D; 2.60.40.1940; -; 1.
DR   Gene3D; 6.20.50.160; -; 1.
DR   Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR   Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 2.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR000020; Anaphylatoxin/fibulin.
DR   InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR   InterPro; IPR001840; Anaphylatoxn_comp_syst_dom.
DR   InterPro; IPR048847; C4_MG1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR019742; MacrogloblnA2_CS.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR041555; MG3.
DR   InterPro; IPR040839; MG4.
DR   InterPro; IPR001134; Netrin_domain.
DR   InterPro; IPR018933; Netrin_module_non-TIMP.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   InterPro; IPR008993; TIMP-like_OB-fold.
DR   PANTHER; PTHR11412:SF86; COMPLEMENT C4-A-RELATED; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF01821; ANATO; 1.
DR   Pfam; PF21145; C4_MG1; 1.
DR   Pfam; PF01835; MG2; 1.
DR   Pfam; PF17791; MG3; 1.
DR   Pfam; PF17789; MG4; 1.
DR   Pfam; PF01759; NTR; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   PRINTS; PR00004; ANAPHYLATOXN.
DR   SFLD; SFLDG01179; Complement_C3/C4_Like; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SMART; SM00104; ANATO; 1.
DR   SMART; SM00643; C345C; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR   SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR   SUPFAM; SSF50242; TIMP-like; 1.
DR   PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
DR   PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR   PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
DR   PROSITE; PS50189; NTR; 1.
PE   4: Predicted;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Sulfation {ECO:0000256|ARBA:ARBA00022641};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018};
KW   Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..1725
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015331712"
FT   DOMAIN          683..717
FT                   /note="Anaphylatoxin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS01178"
FT   DOMAIN          1576..1723
FT                   /note="NTR"
FT                   /evidence="ECO:0000259|PROSITE:PS50189"
SQ   SEQUENCE   1725 AA;  190669 MW;  324C4B4D8319944B CRC64;
     MRLLWGLIWA SSFFTLSLQK PRLLLFSPSV VHLGVPLSVG VQLQDVVKGS VFLRNPSHNN
     VPCSPKVDFT LSSERDFALL SLQVPLKDAK RCGLHQLLRG PEVQLVAHSP WLKDSLSRTT
     NIQGINLLFS SRRGHLFLQT DQPIYNPGQR VRYRVFALDQ KMRPSTDTIT VTVENSHGLR
     VRKKEVYMPS PGTWKISARF SDGLESNSST QFEVKKYVLP NFEVKITPGK PYILTVPGHL
     DEMQLDIQAR YIYGKPVQGV AYVRFGLLDE DGKKTFFRGL ESQTKLVNGQ SHISLSKAEF
     QDALEKLNMG ITDLQGLRLY VAAAIIESPG GEMEEAELTS WYFVSSPFSL DLSKTKRHLV
     PGAPFLLQAL VREMSGSPAS GIPVKVSATV SSPGSVPEVQ DIQQNTDGSG QVSISIIMPQ
     TVSELQLSVS AGSPHPAIAR LTVAAPPSGG PGFLSIERPD SRPPRVGDTL NLNLRAVGSG
     ATFSHYYYMI LSRGQIVFMN REPKRTLTSV SVFVDHHLAP SFYFVAFYYH GDHPVANSLR
     VDVQAGACEG KLELSVDGAK QYRNGESVKL HLETDSLALV ALGALDTALY AAGSKSHKPL
     NMGKVFEAMN SYDLGCGPGG GDSALQVFQA AGLAFSDGDQ WTLSRKRLSC PKEKTTRKKR
     NVNFQKAINE KLGQYASPTA KRCCQDGVTR LPMMRSCEQR AARVQQPDCR EPFLSCCQFA
     ESLRKKSRDK GQAGLQRALE ILQEEDLIDE DDIPVRSFFP ENWLWRVETV DRFQILTLWL
     PDSLTTWEIH GLSLSKTKGL CVATPVQLRV FREFHLHLRL PMSVRRFEQL ELRPVLYNYL
     DKNLTVSVHV SPVEGLCLAG GGGLAQQVLV PAGSARPVAF SVVPTAAAAV SLKVVARGSF
     EFPVGDAVSK VLQIEKEGAI HTEELVYELN PLDHRGRTLE IPGNSDPNMI PDGDFNSYVR
     VTASDPLDTL GSEGALSPGG VASLLRLPRG CGEQTMIYLA PTLAASRYLD KTEQWSTLPP
     ETKDHAVDLI QKGYMRIQQF RKADGSYAAW LSRDSSTWLT AFVLKVLSLA QEQVGGSPEK
     LQETSNWLLS QQQADGSFQD LCPVLDRSMQ GGLVGNDETV ALTAFVTIAL HHGLAVFQDE
     GAEPLKQRVE ASISKANSFL GEKASAGHLG AHAAAITAYA LTLTKAPADL RGVAHNNLMA
     MAQETGDNLY WGSVTGSQSN AVSPTPAPRN PSDPMPQAPA LWIETTAYAL LHLLLHEGKA
     EMADQAAAWL TRQGSFQGGF RSTQDTVIAL DALSAYWIAS HTTEERGLNV TLSSTGRNGF
     KSHALQLNNR QIRGLEEELQ FSLGSKINVK VGGNSKGTLK VLRTYNVLDM KNTTCQDLQI
     EVTVKGHVEY TMEANEDYED YEYDELPAKD DPDAPLQPVT PLQLFEGRRN RRRREAPKVV
     EEQESRVHYT VCIWRNGKVG LSGMAIADVT LLSGFHALRA DLEKLTSLSD RYVSHFETEG
     PHVLLYFDSV PTSRECVGFE AVQEVPVGLV QPASATLYDY YNPERRCSVF YGAPSKSRLL
     ATLCSAEVCQ CAEGKCPRQR RALERGLQDE DGYRMKFACY YPRVEYGFQV KVLREDSRAA
     FRLFETKITQ VLHFTKDVKA TANQMRNFLV RASCRLRLEP GKEYLIMGLD GATYDLEGHP
     QYLLDSNSWI EEMPSERLCR STRQRAACAQ LNDFLQEYGT QGCQV
//

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