ID A0A2R9AYH8_PANPA Unreviewed; 3271 AA.
AC A0A2R9AYH8;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Pericentrin {ECO:0000313|Ensembl:ENSPPAP00000022290.1};
GN Name=PCNT {ECO:0000313|Ensembl:ENSPPAP00000022290.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000022290.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000022290.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000022290.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
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DR EMBL; AJFE02083946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02083947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02083948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02083949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02083950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02083951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02083952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02083953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02083954; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02083955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008975740.1; XM_008977492.1.
DR STRING; 9597.ENSPPAP00000022290; -.
DR Ensembl; ENSPPAT00000045098.1; ENSPPAP00000022290.1; ENSPPAG00000034343.1.
DR GeneTree; ENSGT00730000110871; -.
DR OMA; EQRGMFT; -.
DR OrthoDB; 3030508at2759; -.
DR Proteomes; UP000240080; Chromosome 21.
DR Bgee; ENSPPAG00000034343; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005814; C:centriole; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0007052; P:mitotic spindle organization; IEA:Ensembl.
DR GO; GO:0090316; P:positive regulation of intracellular protein transport; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR InterPro; IPR028745; AKAP9/Pericentrin.
DR InterPro; IPR019528; PACT_domain.
DR PANTHER; PTHR44981:SF3; PERICENTRIN; 1.
DR PANTHER; PTHR44981; PERICENTRIN-LIKE PROTEIN, ISOFORM F; 1.
DR Pfam; PF10495; PACT_coil_coil; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 3074..3151
FT /note="Pericentrin/AKAP-450 centrosomal targeting"
FT /evidence="ECO:0000259|Pfam:PF10495"
FT REGION 1..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1554..1574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2103..2155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2253..2305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2347..2380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2810..2845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3015..3061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3159..3234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 201..486
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 620..686
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1023..1071
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1293..1384
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1413..1540
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1576..1617
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1642..1687
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1727..1818
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2569..2688
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2729..2802
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2852..2923
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2119..2137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2355..2369
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2810..2830
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3015..3034
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3187..3201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3214..3234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3271 AA; 370928 MW; 1BCC1BDE43263716 CRC64;
MEVEQEQRRR KVEAGRTKLA HFRQRKTKGD SSHSEKKTAK RKGSAVNASV QEESPVTKED
SALCGGGDIC KGTSCDDTPD GAGGAFAAQP EDCDGEKRED LEQLQQKQVS DHPPEQRGMF
TVSDHQPEQR GMFTISDHPG EQRGMFTKEC EQECELAITD LESGREDEAG LQQSQAVHGL
ELEALRLSLS NMHTAQLELT QANLQKEKET ALTELREMLN SRRAQELALL QSRQQHELEL
LREQHAREKE EVVLRCGQEA AELKEKLQSE MEKNAQIVKT LKEDWESEKD LCLENLRKEL
SAKHQSEMED LQNQFQKELA EQRAELEKIF QDKNQAERAL RNLESHHQAA IEKLREDLQS
EHGRCLEDLE FKFKESEKEK QLELENLQAS YEDLKAQSQE EIRRLWSQLD SARTSRQELS
ELHEQLLARA SRVEDLEQLK QREKTQHESE LEQLRIYFEK KLRDAEKTYQ EDLTLLQQRL
QGAREDALLD SVEVGLSCVG LEEKPEKGRK DHVDELEPER HKESLPRFQA ELEESHRHQL
EALESPLCIQ HEGHVSDRCC VETSALGHEW RLEPSEGHSQ ELPWVHLQGV QDGDLEADTE
GAARVLGLET EHKVQLSLLQ TELKEEIELL KIENRNLYEK LQHETRLKDD LEKVKHNLIE
DHQKELNNAK QKTELMKQEF RRKETDWKVL KEELQREAEE KLTSMLLELR EKAESEKQTI
INKFELREAE MRQLQDQQAA QILDLERSLT EQQGRLQQLE QDLTSDDALH CSQCGREPPT
AQDGELAALH VKEDCALQLM LARSRFLEER KEITEKFSAE QDAFLQEAQE QHARELRLLQ
ERHQQQLLSV TAELEARHQA ALGELTASLE SKQGALLAAR VAEMQTKHAA DLSALETRHL
SSLDSLESCY LSEFQTIREE HRQALELLRA DFEEQLQKKD SLHQTILTQE LEKLKRKHDR
ELQSVRDHLR TEVSTELAGT MAHELQGVHQ GEFGSEKKTA LHEKEETLRL QSAQAQPFHQ
EEKESLSLQL QKKNHQVQQL KDQVLSLSHE IQECRSELEV LQQRRERENR EGANLLSMLK
ADVDLSHSER GALQDALRRL LGLFGETLRA AVTLRSRIGE RVGLCLDDAG AGLAPSAAPA
LEETWSDVAL LELDRTLSEC AEMSSVAEIS SHMRESFLMS PESVRECEQP IRRVFQSLSL
AVDGLMEMAL DSSRQLEEAR QIHSRFEKEF SFKNEETAQV VRKHQELLEC LKEESTAKAE
LALELHKTQG TLEGFKVETA DLKEALAGKE DSEHRLVLEL ESLRRQLQQA AQEQAALREE
CTRLWSQGEA TATDAEAREA ALRKEVEDLT KEQSETRKQA EKDRSALLSQ MKILESELEE
QLSQHRGCAK QAEAVTALEQ QVASLDKHLR NQRQFMDEQA AEREHEREEF QQEIQRLEGQ
LRQAAKPQPW GPRDSQQAPL DGEVELLRQK LREKLDEFNE LALQKESADR QVLMQEEEIK
RLEEMNINIR KKVAQLQEEV EKQKNVVKGL EQDKEVLKKQ QMSSLLLAST LQSTLDAGRC
PEPPSGSPPE GPEVQLEVTQ RALLRHESEV LDLKEQLEKM KGDLESKNEE ILHLNLKLDM
QNSQTAVSLR ELEEENTSLK VIYTRSSEIE ELKATIENLQ ENQKRLQKEK AEEIEQLHEV
IEKLQHELSL MGPVVHEVSD SQAGSLQSEL LCSQAGGPRG QTLQGELEAA LEAKEALSRL
LADQERRHSQ ALEALQQRLQ GAEEAAELQL AELERNVALR EAEVEDMASR IQEFEAALKA
KEAMIAERNL EIDTLNQRKA AHSAELEAVL LALARIRRAL EQQPLAAGAE PPELQWLRAQ
CARLSRQLQV LHQRFLRCQV ELDRRHARRA TAHTRVPGAH PQLRMDGGAK TQVTGDVEAS
HDAALEPVVP DPQGDLQPVL VTLKDAPLCK QEGVMSVLTV CQRQLQSELL LVKNEMRLSL
EDGGKGKEKV LEDCQLPKVD LVAQVKQLQE KLNHLLYSMT FQNVDAADTK SPWPMASAHL
LESSWSDDSC DGEEPDISPP IDTCDANTAM GGVTDVIKNQ AIDACDANTT TGGVTDVIKN
WDSLIPDEMP DSPIQEKSEC QDRSLSSPTS VLGGSHHQSH TAEAGPRKSP VGMLDLSSWS
SPEVLRKDWT LEPRPSLPVT PHSGALSLCS ADTSLGDRAD TSLPQTQGPG LLCSPGVSTA
ALALQWAESP PADDHHVQRT AVEKDVEDFI TTSFDSQETL SSPPPGLEGK ADRSEKSDGS
GFGARLSPGS GGPEARTAGP VTPAPISGRF QPLPEAMKEK EVHPKHVKAL LQMVRDESHQ
ILALSEGLAP PSGEPHPPRK EDEIQDSSLH GGKTQEVPTA CPDWRGDLLQ VVQEAFEKEQ
EMQGVELQPR LSGSDLGGHS SLLERLEKII REQGDLQEKS LEHLRLLDRS SLLSEIQALR
AQLRMTHLQN QEKLQHLRTA LTSAQARGSQ QEHQLRRQVE LLAYKVEQEK CIAGDLQKTL
SEEQEKANGV QKLLAAEQTV VRDLKSDLCE SRQKNEQLSR SLCEVQQEVL QLRSMLSSKE
NELKAALQEL ESEQGKGRAL QSQLEEEQLR HLQREGQSAK ALEELRASLE TQRAQSSRLC
VALKHEQTAK DNLQKELRIE HSRCEALLAQ ERSQLSELQK DLAAEKSRTL ELSEALRHER
LLTEQLSQRT QEACVHQDTQ AHHALLRKLK EEKSRVVDLQ AMLEKVQQQA LHSQQQLEAE
AQKHCEALKR EKEVSATLKS TVEALHTQKR ELRCSLERER EKPAWLQAEL EQSHPRLKEQ
EGRKAARRSA EARQSPAAAE QWRKWQRDKE KLRELELQRQ RDLHKIKQLQ QTVRDLESKD
EVPGSRLHLG SARRAAGSDA DHLREQQREL EAMRQRLLSA ARLLTSFTSQ AVDRTVNDWT
SSNEKAVMSL LHTLEELKSD LSRPTSSQKK MAAELQFQFV DVLLKDNVSL TKALSTVTQE
KLELSRAVSK LEKMLKHHLQ KGRSPSRSER SAWKPDETAP QSSLRRPDPG RLPPAASEEA
HTSNVKMEKL YLHYLRAESF RKALIYQKKY LLLLIGGFQD SEQETLSMIA HLGVFPSKAE
RKITSRPFTR FRTAVRVVIA ILRLRFLVKK WQEVDRKGAL AQGKAPRTGP RARRPQSPPR
TRESPPTRDV PSGHTRDPAR GRRLAAAASP HSGGRATPSP NSRLERSLTA SQDPEHSLTE
YIHHLEVIQQ RLGGVLPDST SKKSCHQMIK Q
//
