ID A0A2R9AYU8_PANPA Unreviewed; 722 AA.
AC A0A2R9AYU8;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Phosphodiesterase {ECO:0000256|RuleBase:RU363067};
DE EC=3.1.4.- {ECO:0000256|RuleBase:RU363067};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000022248.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000022248.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000022248.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|RuleBase:RU363067};
CC Note=Binds 2 divalent metal cations per subunit. Site 1 may
CC preferentially bind zinc ions, while site 2 has a preference for
CC magnesium and/or manganese ions. {ECO:0000256|RuleBase:RU363067};
CC -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family.
CC {ECO:0000256|RuleBase:RU363067}.
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DR EMBL; AJFE02069299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02069300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02069301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02069302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02069303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02069304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02069305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02069306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02069307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9AYU8; -.
DR Ensembl; ENSPPAT00000045056.1; ENSPPAP00000022248.1; ENSPPAG00000034143.1.
DR GeneTree; ENSGT00940000156543; -.
DR Proteomes; UP000240080; Chromosome 6.
DR Bgee; ENSPPAG00000034143; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 3.30.450.40; -; 2.
DR Gene3D; 1.10.1300.10; 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR023088; PDEase.
DR InterPro; IPR002073; PDEase_catalytic_dom.
DR InterPro; IPR036971; PDEase_catalytic_dom_sf.
DR InterPro; IPR023174; PDEase_CS.
DR PANTHER; PTHR11347:SF111; CAMP AND CAMP-INHIBITED CGMP 3',5'-CYCLIC PHOSPHODIESTERASE 10A; 1.
DR PANTHER; PTHR11347; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; 1.
DR Pfam; PF01590; GAF; 2.
DR Pfam; PF00233; PDEase_I; 1.
DR PRINTS; PR00387; PDIESTERASE1.
DR SMART; SM00065; GAF; 2.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF55781; GAF domain-like; 2.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS00126; PDEASE_I_1; 1.
DR PROSITE; PS51845; PDEASE_I_2; 1.
PE 3: Inferred from homology;
KW cGMP {ECO:0000256|ARBA:ARBA00022535};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU363067};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR623088-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 385..702
FT /note="PDEase"
FT /evidence="ECO:0000259|PROSITE:PS51845"
FT ACT_SITE 458
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR623088-1"
FT BINDING 458..462
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000256|PIRSR:PIRSR623088-2"
FT BINDING 462
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR623088-3"
FT BINDING 496
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR623088-3"
FT BINDING 497
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000256|PIRSR:PIRSR623088-2"
FT BINDING 497
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR623088-3"
FT BINDING 497
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR623088-3"
FT BINDING 607
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000256|PIRSR:PIRSR623088-2"
FT BINDING 607
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR623088-3"
FT BINDING 659
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000256|PIRSR:PIRSR623088-2"
SQ SEQUENCE 722 AA; 81879 MW; 30523498307AE328 CRC64;
MQYLQRAVKQ STIKMMYASA DIQKYICWYQ DTNMQGVVYE LNSYIEQRLD TGGDNQLLLY
ELSSIIKIAT KADGFALYFL GECNNSLCIF TPPGIKEGKP RLIPAGPITQ GTTVSAYVAK
SRKTLLVEDI LGDERFPGGT GLESGTRIQS VLCLPIVTAI GDLIGILELY RHWGKEAFCL
SHQEVATANL AWASVAIHQV QVCRGLAKQT ELNDFLLDIY AKNLVNADRC ALFQVDHKNK
ELYSDLFDIG EEKEGKPVFK KTKEIRFSIE KGIAGQVART GEVLNIPDAY ADPRFNREVD
LYTGYTTRNI LCMPIVSRGS VIGVVQMVNK ISGSAFSKTD ENNFKMFAVF CALALHCANM
YHRIRHSECI YRVTMEKLSY HSICTSEEWQ GLMQFTLPVR LCKEIELFHF DIGPFENMWP
GIFVYMVHRS CGTSCFELEK LCRFIMSVKK NYRRVPYHNW KHAVTVAHCM YAILQNNHTL
FTDLERKGLL IACLCHDLDH RGFSNSYLQK FDHPLAALYS TSTMEQHHFS QTVSILQLEG
HNIFSTLSSS EYEQVLEIIR KAIIATDLAL YFGNRKQLEE MYQTGSLNLN NQSHRDRVIG
LMMTACDLCS VTKLWPVTKL TANDIYAEFW AEGDEMKKLG IQPIPMMDRD KKDEVPQGQL
GFYNAVAIPC YTTLTQILPP TEPLLKACRD NLSQWEKVIR GEETATWISS PSVAQKAAAS
ED
//
