ID A0A2R9B0C7_PANPA Unreviewed; 671 AA.
AC A0A2R9B0C7;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Outer dynein arm-docking complex subunit 4 {ECO:0000256|ARBA:ARBA00034139};
DE AltName: Full=Tetratricopeptide repeat protein 25 {ECO:0000256|ARBA:ARBA00034143};
GN Name=ODAD4 {ECO:0000313|Ensembl:ENSPPAP00000021591.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000021591.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000021591.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000021591.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000256|ARBA:ARBA00004430}.
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DR EMBL; AJFE02044442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02044443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02044444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02044445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02044446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02044447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02044448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02044449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9B0C7; -.
DR STRING; 9597.ENSPPAP00000021591; -.
DR Ensembl; ENSPPAT00000044394.1; ENSPPAP00000021591.1; ENSPPAG00000034013.1.
DR GeneTree; ENSGT00390000007911; -.
DR OMA; NKEDLCF; -.
DR Proteomes; UP000240080; Chromosome 17.
DR Bgee; ENSPPAG00000034013; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0097728; C:9+0 motile cilium; IEA:Ensembl.
DR GO; GO:0097729; C:9+2 motile cilium; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0120228; C:outer dynein arm docking complex; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0090660; P:cerebrospinal fluid circulation; IEA:Ensembl.
DR GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0030324; P:lung development; IEA:Ensembl.
DR GO; GO:0120197; P:mucociliary clearance; IEA:Ensembl.
DR GO; GO:0036158; P:outer dynein arm assembly; IEA:Ensembl.
DR GO; GO:0120229; P:protein localization to motile cilium; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR040111; ODAD4.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR23040:SF1; OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR23040; UNCHARACTERIZED; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 359..392
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 157..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 442..469
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 598..671
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 671 AA; 76309 MW; 2D18FA7F9D5761FD CRC64;
MSDPEGETLR STFPSYMAEG ERLYLCGESK AAQSFSNALY LQDGDKNCLV ARSKCFLKMG
DLERSLKDAE ASLQSDPAFC KGILQKAETL YTMGDFEFAL VFYHRGYKLR PDREFRVGIQ
KAQEAINNSV GSPSSIKLEN KGDLSFLSKQ AENIKAQQKP QPMKHLLHPT KGEPQRKGSL
KSEKTVRQLL GELYVDKEYL EKLLLDEDLI KGTMKGGLTV EDLIMTGINY LDTHSNFWRQ
QKPIYARERD RKLMQEKWLR DHKRRPSQTA HYILKSLEDI DMLLTSGSAE GSLQKAEKVL
KKVLEWNKEE VPNKDELVGN LYSCIGNAQI DLGQMEAALQ SHRKDLEIAK EYDLPDAKSR
ALDNIGRVFA RVGKFQQAID TWEEKIPLAK TTLEKTWLFH EIGRCYLELD QAWQAQNYGE
KSQQCAKEEG DIEWQLNASV LVAQAQVKLR DFESAVNNFE KALERAKLVH NNEAQQAIIS
ALDDANKGII GELRKTNYME NLKEKSEGEA SLYEDRIITR EKDMRRVRDE PEKVVKQWDH
IEDEKETDED DEAFGEALQS PASGKQSVEA GKARSDLGAV AKGLSGELGT RSGETGGKLL
EAGRRESREI YRRPSGELEQ RLSGEFSRQE PEELKKLSEV GRREPEELGK TQFGEIGETK
KTGNEMEKEY E
//
