ID A0A2R9B173_PANPA Unreviewed; 969 AA.
AC A0A2R9B173;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Multifunctional ROCO family signaling regulator 1 {ECO:0000313|Ensembl:ENSPPAP00000023281.1};
GN Name=MFHAS1 {ECO:0000313|Ensembl:ENSPPAP00000023281.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000023281.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000023281.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2R9B173; -.
DR STRING; 9597.ENSPPAP00000023281; -.
DR Ensembl; ENSPPAT00000046103.1; ENSPPAP00000023281.1; ENSPPAG00000034826.1.
DR GeneTree; ENSGT00940000158928; -.
DR OMA; IVCPKNG; -.
DR Proteomes; UP000240080; Unplaced.
DR Bgee; ENSPPAG00000034826; Expressed in adult mammalian kidney and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0051721; F:protein phosphatase 2A binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0035308; P:negative regulation of protein dephosphorylation; IEA:Ensembl.
DR GO; GO:1900181; P:negative regulation of protein localization to nucleus; IEA:Ensembl.
DR GO; GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway; IEA:Ensembl.
DR GO; GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:1900745; P:positive regulation of p38MAPK cascade; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0034137; P:positive regulation of toll-like receptor 2 signaling pathway; IEA:Ensembl.
DR GO; GO:0043030; P:regulation of macrophage activation; IEA:Ensembl.
DR GO; GO:0034121; P:regulation of toll-like receptor signaling pathway; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.30.70.1390; ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020859; ROC_dom.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF39; MALIGNANT FIBROUS HISTIOCYTOMA-AMPLIFIED SEQUENCE 1 HOMOLOG; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 10.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 12.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF82615; Polo-box domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS51424; ROC; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 320..566
FT /note="Roc"
FT /evidence="ECO:0000259|PROSITE:PS51424"
SQ SEQUENCE 969 AA; 108401 MW; 4A18F7657CED4B23 CRC64;
SALGSLRVLV LRRNRFARLP PAVAELGHHL TELDVSHNRL TALGAEVVSA LRELRKLNVS
HNQLPALPAQ LGALAHLEEL DVSFNRLAHL PDSLSCLSRL RTLDVDHNQL TAFPRQLLQL
AALEELDVSS NRLRGLPEDI SALRALKILW LSGAELGTLP AGFCELASLE SLMLDNNGLQ
ALPAQFSCLQ RLKMLNLSSN LFEEFPAALL PLAGLEELYL SRNQLTSVPS LISGLGRLLT
LWLDNNRIRY LPDSIVELTG LEELVLQGNQ IAVLPDHFGQ LSRVGLWKIK DNPLIQPPYE
VCMKGIPYIA AYQKELAHSQ PAVQPRLKLL LMGHKAAGKT LLRHCLTEER VEGFPGGGDK
EKCYPPSPPP VSKGIEVTSW TADASRGLRF IVYDLAGDES YEVIQPFFLS PGALYVLVVN
LATYEPRHFP TTVGSFLHRV GARVPHAVVC IVGTHADLCG ERELEEKCLD IHRQIALQEK
HDAEGLSRLA KVVDEALARD FELRSASPHA AYYGVSDKNL RRRKAHFQYL LNHRLQILSP
VLPVSCRDPR HLRRLRDKLL SVAEHREIFP NLHRVLPRSW QVLEELHFQP PQAHRLWLSW
WDSARLGLQA GLTEDRLQSA LSYLHESGKL LYFEDSPALK EHVFHNLTRL IDILNVFFQR
DPSLLLHKLL LGTSGEGKAE GESSSPMARS TPSQELLRAT QLHQYVEGFL LHGLLPAHVI
RLLLKPHVQA QQDLQLLLEL LEKMGLCYCL NKPKGKPLNG STAWYKFPCY VQNEVPHAEA
WINGTNLAGQ SFVAEQLQIE YSFPFAFPPG LFARYSVQIN SHVVHRSDGK FQIFAYRGKV
PVVVSYRPAR GVLQPDTLSI ASHASLPNIW TAWQAITPLV EELNVLLQEW PGLHYTVHIL
CSKCLKRGSP NPHAFPGELL SQPRPEGVAE IICPKNGSER VNVALVYPPT PTVISPCSKK
NVGEKHRNQ
//
