ID A0A2R9B1D6_PANPA Unreviewed; 941 AA.
AC A0A2R9B1D6;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=MCF.2 cell line derived transforming sequence {ECO:0000313|Ensembl:ENSPPAP00000022893.1};
GN Name=MCF2 {ECO:0000313|Ensembl:ENSPPAP00000022893.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000022893.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000022893.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000022893.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AJFE02038991; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003812351.1; XM_003812303.3.
DR AlphaFoldDB; A0A2R9B1D6; -.
DR Ensembl; ENSPPAT00000045708.1; ENSPPAP00000022893.1; ENSPPAG00000034608.1.
DR GeneID; 100996184; -.
DR CTD; 4168; -.
DR GeneTree; ENSGT00940000156974; -.
DR OrthoDB; 4244290at2759; -.
DR Proteomes; UP000240080; Chromosome X.
DR Bgee; ENSPPAG00000034608; Expressed in prefrontal cortex and 2 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR PANTHER; PTHR22826:SF146; PROTO-ONCOGENE DBL; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 13..88
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 511..691
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 703..825
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT COILED 244..274
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 941 AA; 109567 MW; 251409BD73B9FF09 CRC64;
MAEANPRRGK MRFRRNAASF PGNLHLVLVL RPTSFLQRTF TDIGFWFSQE DFMLKLPVVM
LSSVSDLLTY IDDKQLTPEL GGTLQYCHSE WIIFRNAIEN FALTVKEMAQ MLQSFGTELA
ETELPDDIPS IEEILAIRAE RYHLLKNDIT AVTKEGKILL TNLEVPDTEG AVSSRLECHR
QISGDWQTIN KLLTQVHDME TAFDGFWEKH QLKMEQYLQL WKFEEDFQQL VTEVEFLLNQ
QAELADVTGT IAQVKQKIKK LENLDENSQE LLSKAQFVIL HGHKLAANHH YALDLICQRC
NELRYLSDIL VNEIKAKRIQ LSRTFKMHKL LQQARQCCDE GECLLANQEI DKFQSKEDAQ
KALQDIENFL EMALPFINYE PETLQYEFDV ILSPELKVQM KTIQLKLENI RSIFENQQAG
FRNLADKHVR PIQFVVPTPE NLVTSGTPFF SSKQVGVGYS FFQACKLFSK GKKTWRQNQS
NLKIEVVHDC QEKRSSGQSS SLDNGNSLDV LKNHVLNELI QTERVYVREL YTVLLGYRAE
MDNPEMFDLM PPLLRNKKDI LFGNMAEIYE FHNDIFLSSL ENCAHAPERV GPCFLERKDD
FQMYAKYCQN KPRSETIWRK YSECAFFQEC QRKLKHRLRL DSYLLKPVQR ITKYQLLLKE
LLKYSKDCEG SALLKKALDA MLDLLKSVND SMHQIAINGY IGNLNELGKM IMQGGFSVWI
GHKKCATKMK DLARFKPMQR HLFLYEKAIV FCKRRVESGE GSDRYPSYSF KHCWKMDEVG
ITEYVKGDNR KFEIWYGEKE EVYIVQASNV DVKMTWLKEI RNILLKQQEL LTVKKRKQQD
QLTERDKFQI SLQQNDEKQQ GAFVSTEETE LEHTNTVVEV CEAIASVQAE ANTVWTEASQ
SAEISEEPAE WSSNYFYPTY DENEEENRPL MRPVSEMALL Y
//
