ID A0A2R9B2B8_PANPA Unreviewed; 1137 AA.
AC A0A2R9B2B8;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 5 {ECO:0000313|Ensembl:ENSPPAP00000022297.1};
GN Name=TRPM5 {ECO:0000313|Ensembl:ENSPPAP00000022297.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000022297.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000022297.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000022297.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJFE02054294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02054295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9B2B8; -.
DR STRING; 9597.ENSPPAP00000022297; -.
DR Ensembl; ENSPPAT00000045105.1; ENSPPAP00000022297.1; ENSPPAG00000034292.1.
DR GeneTree; ENSGT00940000160588; -.
DR OMA; CYCTAVI; -.
DR Proteomes; UP000240080; Chromosome 11.
DR Bgee; ENSPPAG00000034292; Expressed in adult mammalian kidney and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:Ensembl.
DR GO; GO:0005267; F:potassium channel activity; IEA:Ensembl.
DR GO; GO:0005272; F:sodium channel activity; IEA:Ensembl.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF5; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 5; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 692..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 776..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 838..859
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 914..934
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..261
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 707..950
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 477..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1106..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1137 AA; 127658 MW; 87B9C51695C9C643 CRC64;
MQDVQGPRPG SPGDAEDRRE LGLHRGEVDF GGSGKKRGKF VRVPSGVAPS VLFDLLLAEW
HLPAPNLVEQ TFAMKSWLRD VLRKGLVKAA QSTGAWILTS ALRVGLARHV GQAVRDHSLA
STSTKVRVVA VGMASLGRVL HRRILEEAQD FPVHYPEDDG GSQGPLCSLD SNLSHFILVE
PGPPGKGDGL TELRLRLEKH ISEQRAGYGG TGSIEIPVLC LLVNGDPSTL ERISRAVEQA
APWLILAGSG GIADVLAALV NQPHLLVPKV AEKQFKEKFP SEHFSWEDIV RWTKLLQNIT
SHQHLLTVYD FEQEGSEELD TVILKALVKA CKSHSQEPQD YLDELKLAVA WDRVDIAKSE
IFNGDVEWKS CDLEEVMVDA LVSNKPEFVR LFVDNGADVA DFLTYGRLQE LYRSVSRKSL
LFDLLQRKQE EARLTLAGLG TQQAREPPAG PPAFSLHEVS RVLKDFLQDA CRGFYQDGRP
GGRRRAVKGP GQAAHGPEVP RPRAQRRGVA AALAACKILK EMSHLETEAE AARAMREAKY
EQLALDLFSE CYSNSEARAF ALLVRRNRCW SKTTCLHLAT EADAKAFFAH DGVQAFLTRI
WWGDMAAGTP ILRLLGAFLC PALVYTNLIT FSEEAPLRTG LEDLQDLDSL DTEKSPLYGL
QSRVEELVEA PRAQGDRGPR AVFLLTRWRK FWGAPVTVFL GNVVMYFAFL FLFTYVLLVD
FRPPPQGPSG PEVTLYFWVF TLVLEEIRQG FFTDEDTHLV KKFTLYVGDN WNKCDMVAIF
LFIVGVTCRM LPSAFEAGRT VLAMDFMVFT LRLIHIFAIH KQLGPKIIVV ERMMKDVFFF
LFFLSVWLVA YGVTTQALLH PHDGRLEWIF RRVLYRPYLQ IFGQIPLDEI DEARVNCSTH
PLLLEDSPSC PSLYANWLVI LLLVTFLLVT NVLLMNLLIA MFSYTFQVVQ GNADMFWKFQ
RYNLIVEYHE RPALAPPFIL LSHLSLALRR VFKKEAEHKR EHLERDLPDP LDQKVVTWET
VQKENFLSKM EKRRRDSEGE VLRKTAHSLT ACSCRRVDFV AKYLGGLREQ EKRIKCLESQ
INYCSVLVSS VADVLAQGGG PWSSQHCGEG SQLVAADHRG GLDGREQPGA GQPPSDT
//
