ID A0A2R9B4N2_PANPA Unreviewed; 2392 AA.
AC A0A2R9B4N2;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Centromere protein E {ECO:0000313|Ensembl:ENSPPAP00000022391.1};
GN Name=CENPE {ECO:0000313|Ensembl:ENSPPAP00000022391.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000022391.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000022391.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000022391.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; AJFE02105002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02105003; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPPAT00000045201.1; ENSPPAP00000022391.1; ENSPPAG00000034329.1.
DR GeneTree; ENSGT00940000160597; -.
DR OMA; MQSVEMD; -.
DR Proteomes; UP000240080; Chromosome 4.
DR Bgee; ENSPPAG00000034329; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd01374; KISc_CENP_E; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47968; CENTROMERE PROTEIN E; 1.
DR PANTHER; PTHR47968:SF36; CENTROMERE-ASSOCIATED PROTEIN E; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 6..329
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 1938..1966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2234..2254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 338..365
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 493..579
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 609..751
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 801..968
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1027..1058
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1083..1246
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1298..1360
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1405..1513
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2204..2231
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2255..2303
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 86..93
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 2392 AA; 281084 MW; A081BE9D355BF389 CRC64;
MAEEGAVAVC VRVRPLNSRE ESLGETAQVY WKTDNNVIYQ VDGSKSFNFD RVFHGNETTK
NVYEEIAAPI IDSAIQGYNG TIFAYGQTAS GKTYTMMGSE DHLGVIPRAI HDIFQKIKKF
PDREFLLRVS YMEIYNETIT DLLCGTQKMK PLIIREDVNR NVYVADLTEE VVYTSEMALK
WITKGEKSRH YGETKMNQRS SRSHTIFRMI LESREKGEPS NCEGSVKVSH LNLVDLAGSE
RAAQTGAAGV RLKEGCNINR SLFILGQVIK KLSDGQVGGF INYRDSKLTR ILQNSLGGNA
KTRIICTITP VSFDETLTAL QFASTAKYMK NTPYVNEVST DEALLKRYRK EIMDLKKQLE
EVSLETRAQA MEKDQLTQLL EEKDLLQKVQ NEKIENLTRM LVTSSSLTLQ QELKDKRKRR
VTWCLGKINK MKSSNYADQF NMPTNITTKT HKLSINLLRE IDESVCSESD VFSNTLDTLS
EIEWNPATKL LNQENIESEL NSLRADYDNL VLDYEQLRTE KEEMELKLKE KNDLDEFEAL
ERKTKKDQEN ELSSKVELLR EKEDQIKKLQ EYIDSQKLEN IKMDLSYSLE SIEDPKQMKQ
TLFDAETVAL DAKRESAFLR SENLELKEKM KELATTYKQM ENDIQLYQSQ LEAKKKMQVD
LEKELQSAFN EITKLTSLID GKVPKDLLCN LELEGKITDL QKELNKEVEE NEALREEVIL
LSELKSLPSE VERLRKEIHD KSEELHIITS EKDKLFSEVV HKESRVQSLL EEIGKTKDDL
ATTQSNYKST DQEFQNFKTL HMDFEQKYKM VLEENERMNQ EIVNLSKEAQ KFDSSLGALK
TELSYKTQEL QEKTREVQER LNEMEQLKEQ LENRDSTLQT VEREKTLITE KLQQTLEEVK
TLTQEKDNLK QLQESLQIER DQLKSDIHDT VNMNIDTQEQ LRNALESLKQ HQETINTLKS
EISEEVSRNL HVEENTGETK DEFQQKMVGI DKKQDLEAKN TQTLTADVKD NEIIKQQRKI
FSLIQEKNEL QQMLESVIAE KEQLKTDLKE NIEMTIENQE ELRLLGDELK KQQQIVAQEK
NHAIKKEEEL SRTCDRLAEV EEKLKEKSQQ LQEKQQQLLN VQEEMSEMQK KINEMENLKN
ELKNKELTLE HMETERLELA QKLNENYEEV KSITKERKVL KELQESFETE RDQLRGYVRE
IEATGLQTKE ELKIAHIHLK EHQETIDELR RSISEKTAQI VNTQDLEKSH TKLQEEIPVL
HEEQELLPNV KEVSETQETM NELELLTEQS TTKDSTTLAR IEMERLRLNE KFQESQEEIK
SLTKERDNLK TIKEALEVKH DQLKEHIRET LAKIQESQSK QEQSLNMKEK HNETTKIVSE
MEQFKPKDSA LLRIEIEMLG LSKRLQESHD EMKSVAKEKD DLQRLQEVLQ SESDQLKENI
KEIVAKHLET EEELKVAHCC LKEQEETINE LRVNLSEKET EISTIQKQLE AINDKLQNKI
QEIYEKEEQL NIKQISEVQE KVNELKQFKE HRKVKHSALQ SIESKMLELT NRLQESQEEI
QIMIKEKEEM KRVQEALQIE RDQLKENTKE IVAEMKESQE KEYQFLKMTA VNETQEKMCE
IDHLKEQFET QKLNLENIET ENIRLTQILH ENLEEMRSVT KERDDLRSVE ETLKVERDQL
KENLRETITR DLEKQEELKI VHMHLKEHQE TIDKLRGIVS EKTNEISNMQ KDLEHSNDAL
KAQDLKIQEE LRIAHMHLKE QQETIDKLRG IVSEKTDKIS NMQKDLENSN AKLQEKIQEL
KANEHQLFKL KKDVNETQKK VSEMEQLKKQ IKDQSLTLSK LEMENLNLAQ KLHENLEEMK
SVMKERDNLR RVEETLKLER DQLKESLQET KARDLEIQQE LKTARMLSKE HKETADKLRE
KISEKTIQIS DIQKDLDKSK DELQKKQDRQ NHQVKPEKRL LSDGQQHLTE SLREKCSRIK
ELLKRYSEMD DHYECLNRLS LDLEKEIEIQ KELSMRVKAN LSLPYLQTKH IEKLFTANQR
CSMEFHRIMK KLKYVLSYVT KIKEEQHESI NKFEMDFIDE VEKQKELLIK IQHLQQDCDV
PSRELRDLKL NQNMDLHIEE ILKDFSESEF PSIKTEFQQV LSNRKEMTQF LEEWLNTRFD
IEKLKNGIQK ENDRICQVNN FFNNRIIAIM NESTEFEERS ATISKEWEQD LKSLKEKNEK
LFKNYQTLKT SLASGAQVNP TTQDNKNPHV TSRATQLTTE KIRELENSLH EAKESAMHKE
SKIIKMQKEL EVTNDIIAKL QAKVHESNKC LEKTKETIQV LQDKVALGAK PYKEEIEDLK
TKLVKIDLEK MKNAKEFEKE ISATKATVEY QKEVIRLLRE NLRRSQQAQD TS
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