ID A0A2R9B4N4_PANPA Unreviewed; 1013 AA.
AC A0A2R9B4N4;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Solute carrier family 12 member 4 {ECO:0000313|Ensembl:ENSPPAP00000024538.1};
GN Name=SLC12A4 {ECO:0000313|Ensembl:ENSPPAP00000024538.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000024538.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000024538.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000024538.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR EMBL; AJFE02038516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02038517; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02038518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02038519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02038520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9B4N4; -.
DR Ensembl; ENSPPAT00000047363.1; ENSPPAP00000024538.1; ENSPPAG00000035394.1.
DR GeneTree; ENSGT00940000157672; -.
DR Proteomes; UP000240080; Chromosome 16.
DR Bgee; ENSPPAG00000035394; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000622; KCC1.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF46; SOLUTE CARRIER FAMILY 12 MEMBER 4; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
DR PRINTS; PR01082; KCLTRNSPORT1.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 111..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..566
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 605..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 116..292
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 410..687
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 701..817
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 832..1013
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1013 AA; 112030 MW; 1452C0539C4CE9FC CRC64;
MPHFTVVPVD GPRRGWGAQE AGPDCPSLFT GHGNHRESSP FLSPLETSRG SDYYDRNLAL
FEEELDIRPK VSSLLGKLVS YTNLTQGAKE HEEAESGEGT RRRAAEAPSM GTLMGVYLPC
LQNIFGVILF LRLTWMVGTA GVLQALLIVL ICCCCTLLTA ISMSAIATNG VVPAGGSYFM
ISRSLGPEFG GAVGLCFYLG TTFAAAMYIL GAIEILLTYI APPAAIFYPS GAHDTSNATL
NNMRVYGTIF LTFMTLVVFV GVKYVNKFAS LFLACVIISI LSIYAGGIKS IFDPPVFPVC
MLGNRTLSRD QFDICAKTAV VDNETVATQL WSFFCHSPNL TTDSCDPYFM LNNVTEIPGI
PGAAAGVLQE NLWSAYLEKG DIVEKHGLPS ADAPSLKESL PLYVVADIAT SFTVLVGIFF
PSVTGIMAGS NRSGDLRDAQ KSIPVGTILA IITTSLVYFS SVVLFGACIE GVVLRDKYGD
GVSRNLVVGT LAWPSPWVIV IGSFFSTCGA GLQSLTGAPR LLQAIAKDNI IPFLRVFGHG
KVNGEPTWAL LLTALIAELG ILIASLDMVA PILSMFFLMC YLFVNLACAV QTLLRTPNWR
PRFKYYHWAL SFLGMSLCLA LMFVSSWYYA LVAMLIAGMI YKYIEYQGAE KEWGDGIRGL
SLSAARYALL RLEEGPPHTK NWRPQLLVLL KLDEDLHVKY PRLLTFASQL KAGKGLTIVG
SVIQGSFLES YGEAQAAEQT IKNMMEIEKV KGFCQVVVAS KVREGLAHLI QSCGLGGMRH
NSVVLGWPYG WRQSEDPRAW KTFIDTVRCT TAAHLALLVP KNIAFYPSNH ERYLEGHIDV
WWIVHDGGML MLLPFLLRQH KVWRKCRMRI FTVAQMDDNS IQMKKDLAVF LYHLRLEAEV
EVVEMHNSDI SAYTYERTLM MEQRSQMLRQ MRLTKTERED QSNVRRMHTA VKLNEVIVTR
SHDARLVLLN MPGPPRNSEG DENYMEFLEV LTEGLERVLL VRGGGREVIT IYS
//
