ID A0A2R9B5A4_PANPA Unreviewed; 912 AA.
AC A0A2R9B5A4;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Scaffold attachment factor B {ECO:0000313|Ensembl:ENSPPAP00000024196.1};
GN Name=SAFB {ECO:0000313|Ensembl:ENSPPAP00000024196.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000024196.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000024196.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000024196.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AJFE02066142; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02066143; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02066144; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02066145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02066146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9B5A4; -.
DR Ensembl; ENSPPAT00000047021.1; ENSPPAP00000024196.1; ENSPPAG00000035129.1.
DR GeneTree; ENSGT00940000155916; -.
DR Proteomes; UP000240080; Chromosome 19.
DR Bgee; ENSPPAG00000035129; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12679; RRM_SAFB1_SAFB2; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR034781; SAFB1_2_RBD.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR PANTHER; PTHR15683; SCAFFOLD ATTACHMENT FACTOR B-RELATED; 1.
DR PANTHER; PTHR15683:SF6; SCAFFOLD ATTACHMENT FACTOR B1; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF02037; SAP; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00513; SAP; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50800; SAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 31..65
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
FT DOMAIN 394..472
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..118
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..536
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..629
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..785
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..850
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 912 AA; 102111 MW; B37D1DD45AE9BF74 CRC64;
MAETLSGLGD SGAAGAAALS SASSETGTRR LSDLRVIDLR AELRKRNVDS SGNKSVLMER
LKKAIEDEGG NPDEIEITSE GNKKTSKRSS KGRKPEEEGV EDNGLEENSG DGQEDVETSL
ENLQDIDIMD ISVLDEAEID NGSVADCVED DDADNLQESL SDSRELVEGE MKELPEQLQE
HAIEDKETIN NLDTSSSDFT ILQKILDILG ETCKSEPVKE ESSELEQPFA QDTSSVGPDR
KLAEEEDLFD SAHPEEGDLD LASESTAHAQ SSKADSLLAV VKREPAEQPG DGERTDCEPV
GLEPAVEQSS AASELAEASS EELAEAPTEA PSPEARDSKE DGRKFDFDAC NEVPPAPKES
STSEGADQKM SSPEDDSDTK RLSKEEKGRS SCGRNFWVSG LSSTTRATDL KNLFSKYGKV
VGAKVVTNAR SPGARCYGFV TMSTAEEATK CINHLHKTEL HGKMISVEKA KNEPVGKKTS
DKRDSDGKKE KSSNSERSTN LKRDDKCDRK DDAKKGDDGS GEKSKDQDDQ KPGPSERSRA
TKSGSRGTER TVVMDKSKGV PVISVKTSGS KERASKSQDR KSASREKRSV VSFDKVKEPR
KSRDSESHSR VRERSEREQR MQAQWEREER ERLEIARERL AFQRQRLERE RMERERLERE
RMHVEHERRR EQERIHRERE ELRRQQELRY EQERRPAVRR PYDLDRRDDA YWPEAKRAAL
DERYHSDFNR QDRFHDFDHR DRGRYPDHSV DRSVGPLLGV RHYPERHGGP ERHGRDSRDG
WGGYGSDKRM SEGRGLPPPP RFYLTAPPPH KGARKRDWGD HGRREDDRSW QGTADGGMMD
RDHKRWQGGE RSMSGHSGPG HMMNRGGMSG RGSFAPGGAS RGHPIPHGGM QGGFGGQSRG
SRPSDARFTR RY
//
