ID A0A2R9B645_PANPA Unreviewed; 460 AA.
AC A0A2R9B645;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=ETS variant transcription factor 6 {ECO:0000313|Ensembl:ENSPPAP00000025058.1};
GN Name=ETV6 {ECO:0000313|Ensembl:ENSPPAP00000025058.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000025058.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000025058.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000025058.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR EMBL; AJFE02104187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02104188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02104189; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02104190; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9B645; -.
DR Ensembl; ENSPPAT00000047884.1; ENSPPAP00000025058.1; ENSPPAG00000035667.1.
DR GeneTree; ENSGT00940000159508; -.
DR Proteomes; UP000240080; Chromosome 12.
DR Bgee; ENSPPAG00000035667; Expressed in placenta and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd08535; SAM_PNT-Tel_Yan; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF19; TRANSCRIPTION FACTOR ETV6; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 48..132
FT /note="PNT"
FT /evidence="ECO:0000259|PROSITE:PS51433"
FT DOMAIN 347..428
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 166..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 460 AA; 54288 MW; 0506CBD3C0A62AC4 CRC64;
MIPKSLLRHR REQDWHGWQQ ERISYTPPES PVPSYASSTP LHVPVPRALR MEEDSIRLPA
HLRLQPIYWS RDDVAQWLKW AENEFSLRPI DSNTFEMNGK ALLLLTKEDF RYRSPHSGDV
LYELLQHILK QRKPRILFSP FFHPGNSIHT QPEVILHQNH EEDNCVQRTP RPSVDNVHHN
PPTIELLHRS RSPITTNHRP SPDPEHRPLR SPLDNMIRRL SPAERAQGPR PHQENNHQES
YPLSVSPMEN NHCPASSESH PKPSSPRQES TRVIQLMPSP IMHPLILNPR HSVDFKQSRL
SEDGLHREGK PINLSHREDL AYMNHIMVSV SPPEEHAMPI GRIADCRLLW DYVYQLLSDS
RYENFIRWED KESKIFRIVD PNGLARLWGN HKNRTNMTYE KMSRALRHYY KLNIIRKEPG
QRLLFRFMKT PDEIMSGRTD RLEHLESQEL DEQIYQEDEC
//
