ID A0A2R9B9Q6_PANPA Unreviewed; 528 AA.
AC A0A2R9B9Q6;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=RRM domain-containing protein {ECO:0000259|PROSITE:PS50102};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000023984.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000023984.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000023984.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}. Cytoplasm, Stress granule
CC {ECO:0000256|ARBA:ARBA00004210}.
CC -!- SIMILARITY: Belongs to the RRM IMP/VICKZ family.
CC {ECO:0000256|ARBA:ARBA00009094}.
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DR EMBL; AJFE02028017; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9B9Q6; -.
DR Ensembl; ENSPPAT00000046809.1; ENSPPAP00000023984.1; ENSPPAG00000035134.1.
DR GeneTree; ENSGT00940000154913; -.
DR OMA; QNWAMRA; -.
DR Proteomes; UP000240080; Chromosome 1.
DR Bgee; ENSPPAG00000035134; Expressed in cerebellum.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.310.210; -; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR10288:SF93; INSULIN-LIKE GROWTH FACTOR 2 MRNA-BINDING PROTEIN 2; 1.
DR PANTHER; PTHR10288; KH DOMAIN CONTAINING RNA BINDING PROTEIN; 1.
DR Pfam; PF00013; KH_1; 4.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00322; KH; 4.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 4.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50084; KH_TYPE_1; 4.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3..76
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 136..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 528 AA; 59167 MW; 42044D89E43069C1 CRC64;
MMNKLYIGNL SPAVTADDLW QLFGDRKLPP AGQVLLKPGY AFVDYPDQNW AMRAIETLPG
QVELYGKIME VDYSVSKKLR SRKIQIQNIP PHLQWEVLDG LLAQNGAVEN VEQVNTDTET
AVVNVTYATR EENSHAEPFK ISYIPDEELS SPSPPQRAQE QGHAPGDVSQ ARQIDFLLRI
LVPTQFVGAI IRKEGLTIKN ITKQTQSRVD IHRKENSGAA EKPVTIHATP GGISEACRMI
LEIMQKEAYE TKLAKEIPLK ILAHNGLVER LTGKEGRNLK KIEHETGTKL AISSLQDLSI
YNQERTITVK GTVEACASAE IEIMKKLRKT FENDMLAVNT HSGYFSSLYP NHRFEQEIVN
LFIPTQAVGT IIRKKGAHIK QLVRFAAASI KITPEEGPDV NERMVIITRP PEAQFKAQGQ
IFGKLKEENF FNPKEEVKLE AHIRVPSSTT GRVIGKGGKT VNELQNLTSA EVIVPRDQTP
DENEEMIVRI IGHFFASPTA QHKIRETVQQ VKQQEQKYPQ GVASQHSK
//
