ID A0A2R9BB10_PANPA Unreviewed; 1090 AA.
AC A0A2R9BB10;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=IQ motif and Sec7 domain ArfGEF 1 {ECO:0000313|Ensembl:ENSPPAP00000026793.1};
GN Name=IQSEC1 {ECO:0000313|Ensembl:ENSPPAP00000026793.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000026793.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000026793.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000026793.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BRAG family.
CC {ECO:0000256|ARBA:ARBA00006248}.
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DR EMBL; AJFE02092235; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02092236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9BB10; -.
DR Ensembl; ENSPPAT00000049629.1; ENSPPAP00000026793.1; ENSPPAG00000036448.1.
DR GeneTree; ENSGT00940000156915; -.
DR Proteomes; UP000240080; Chromosome 3.
DR Bgee; ENSPPAG00000036448; Expressed in prefrontal cortex and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13318; PH_IQSEC; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF327; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 502..695
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 902..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..389
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..944
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1046
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1090 AA; 121832 MW; 9EF74D3CD65ADAC8 CRC64;
MGCQRMVVEG EAPSSETGTS LDSPSAYPQG PLVPGSSLSP DHYEHTSVGA YGLYSGPPGQ
QQRTRRPKLQ HSTSILRKQA EEEAIKRSRS LSESYELSSD LQDKQVEMLE RKYGGRLVTR
HAARTIQTAF RQYQMNKNFE RLRSSMSENR MSRRIVLSNM RMQFSFEGPE KVHSSYFEGK
QVSVTNDGSQ LGALVPPECG DLSEPTTLKS PAPSSDFADA ITELEDAFSR QVKSLAESID
DALNCRSLHT EEAPALDAAR ARDTEPQTAL HGMDHRKLDE MTASYSDVTL YIDEEELSPP
LPLSQAGDRP SSTESDLRLR AGGAAPDYWA LAHKEDKADT DTSCRSTPSL ERQEQRLRVE
HLPLLTIEPP SDSSVDLSDR SERGSLKRQS AYERSLGGQQ GSPKHGPHSG APKSLPREEP
ELRPRPPRPL DSHLAINGSA NRQSKSESDY SDGDNDSINS TSNSNDTINC SSESSSRDSL
REQTLSKQTY HKEARNSWDS PAFSNDVIRK RHYRIGLNLF NKKPEKGVQY LIERGFVPDT
PVGVAHFLLQ RKGLSRQMIG EFLGNRQKQF NRDVLDCVVD EMDFSTMELD EALRKFQAHI
RVQGEAQKVE RLIEAFSQRY CICNPGVVRQ FRNPDTIFIL AFAIILLNTD MYSPNVKPER
KMKLEDFIKN LRGVDDGEDI PREMLIGIYE RIRKRELKTN EDHVSQVQKV EKLIVGKKPI
GSLHPGLGCV LSLPHRRLVC YCRLFEVPDP NKPQKLGLHQ REIFLFNDLL VVTKIFQKKK
NSVTYSFRQS FSLYGMQVLL FENQYYPNGI RLTSSVPGAD IKVLINFNAP NPQDRKKFTD
DLRESIAEVQ EMEKHRIESE LEKQKGVVRP SMSQCSSLKK ESGNGTLSRA CLDDSYASGE
GLKRSALSSS LRDLSEAGKR GRRSSAGSLE SNVEGSIISS PHMRRRATST RECPSRPHQT
MPNSSSLLGS LFGSKRGKPP PPQAHLPSAA HSMAGHHLGP PEGLPQAPVH GHHTQYCHMQ
NPPPYHHHHH HHPPQHIQHA HQYHHGPHGG HPAYGAHAHG HPPLPSAHVG HTAHHHGHSK
AKPSGISTIV
//
