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Database: UniProt
Entry: A0A2R9BDI7_PANPA
LinkDB: A0A2R9BDI7_PANPA
Original site: A0A2R9BDI7_PANPA 
ID   A0A2R9BDI7_PANPA        Unreviewed;       998 AA.
AC   A0A2R9BDI7;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Dynamin-like 120 kDa protein, mitochondrial {ECO:0000256|ARBA:ARBA00018307};
DE            EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
GN   Name=OPA1 {ECO:0000313|Ensembl:ENSPPAP00000027222.1};
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000027222.1, ECO:0000313|Proteomes:UP000240080};
RN   [1] {ECO:0000313|Ensembl:ENSPPAP00000027222.1, ECO:0000313|Proteomes:UP000240080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22722832; DOI=10.1038/nature11128;
RA   Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA   Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA   Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA   Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA   Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA   Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA   Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA   Paabo S.;
RT   "The bonobo genome compared with the chimpanzee and human genomes.";
RL   Nature 486:527-531(2012).
RN   [2] {ECO:0000313|Ensembl:ENSPPAP00000027222.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00001837};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC       inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion membrane
CC       {ECO:0000256|ARBA:ARBA00004325}.
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DR   EMBL; AJFE02022518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02022519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02022520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2R9BDI7; -.
DR   Ensembl; ENSPPAT00000050061.1; ENSPPAP00000027222.1; ENSPPAG00000036156.1.
DR   GeneTree; ENSGT00550000074851; -.
DR   Proteomes; UP000240080; Chromosome 3.
DR   Bgee; ENSPPAG00000036156; Expressed in heart and 6 other cell types or tissues.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   CDD; cd08771; DLP_1; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR045817; OPA1_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11566; DYNAMIN; 1.
DR   PANTHER; PTHR11566:SF67; DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF19434; OPA1_C; 1.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW   Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          342..618
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51718"
FT   COILED          227..310
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   998 AA;  115431 MW;  25EE53CAACBB8956 CRC64;
     VYRGRQASLS CSGEVCQSLV KHSSGIKGSL PLQKLHLVSR SIYHSHHPTL KLQRPQLRTS
     FQQFSSLTNL PLRKLKFSPI KYGYQPRRNF WPARLATRLL KLRYLILGSA VGGGYTAKKT
     FDQWKDMIPD LSEYKWIVPD IVWEIDEYID FEKIRKALPN SEDLVKLAPD FDKIVESLSL
     LKDFFTSGHK LVSEVIGASD LLLLLGSPGE TAFRATDHGS ESDKHFRKGL LGELILLQQQ
     IQEREEEARR AAGQYSTSYA QQKRKVSDKE KIDQLQEELL HTQLKYQRIL ERLEKENKEL
     RKLVLQKDDK GIHHRKLKKS LIDMYSEVLD VLSDYDASYN TQDHLPRVVV VGDQSAGKTS
     VLEMIAQARI FPRGSGEMMT RSPVKVTLSE GPHHVALFKD SSREFDLTKE EDLAALRHEI
     ELRMRKNVKE GCTVSPETIS LNVKGPGLQR MVLVDLPGVI NTVTSGMAPD TKETIFSISK
     AYMQNPNAII LCIQDGSVDA ERSIVTDLVS QMDPHGRRTI FVLTKVDLAE KNVASPSRIQ
     QIIEGKLFPM KALGYFAVVT GKGNSSESIE AIREYEEEFF QNSKLLKTSM LKAHQVTTRN
     LSLAVSDCFW KMVRESVEQQ ADSFKATRFN LETEWKNNYP RLRELDRNEL FEKAKNEILD
     EVISLSQVTP KHWEEILQQS LWERVSTHVI ENIYLPAAQT MNSGTFNTTV DIKLKQWTDK
     QLPNKAVEVA WETLQEEFSR FMTEPKGKEH DDIFDKLKEA VKEESIKRHK WNDFAEDSLR
     VIQHNALEDR SISDKQQWDA AIYFMEEALQ ARLKDTENAI ENMVGPDWKK RWLYWKNRTQ
     EQCVHNETKN ELEKMLKCNE EHPAYLASDE ITTVRKNLES RGVEVDPSLI KDTWHQVYRR
     HFLKTALNHC NLCRRGFYYY QRHFVDSELE CNDVVLFWRI QRMLAITANT LRQQLTNTEV
     RRLEKNVKEV LEDFAEDGEK KIKLLTGKRV QLAEDLSE
//
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