ID A0A2R9BDI7_PANPA Unreviewed; 998 AA.
AC A0A2R9BDI7;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Dynamin-like 120 kDa protein, mitochondrial {ECO:0000256|ARBA:ARBA00018307};
DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
GN Name=OPA1 {ECO:0000313|Ensembl:ENSPPAP00000027222.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000027222.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000027222.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000027222.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001837};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion membrane
CC {ECO:0000256|ARBA:ARBA00004325}.
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DR EMBL; AJFE02022518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02022519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02022520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9BDI7; -.
DR Ensembl; ENSPPAT00000050061.1; ENSPPAP00000027222.1; ENSPPAG00000036156.1.
DR GeneTree; ENSGT00550000074851; -.
DR Proteomes; UP000240080; Chromosome 3.
DR Bgee; ENSPPAG00000036156; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR045817; OPA1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF67; DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF19434; OPA1_C; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 342..618
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT COILED 227..310
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 998 AA; 115431 MW; 25EE53CAACBB8956 CRC64;
VYRGRQASLS CSGEVCQSLV KHSSGIKGSL PLQKLHLVSR SIYHSHHPTL KLQRPQLRTS
FQQFSSLTNL PLRKLKFSPI KYGYQPRRNF WPARLATRLL KLRYLILGSA VGGGYTAKKT
FDQWKDMIPD LSEYKWIVPD IVWEIDEYID FEKIRKALPN SEDLVKLAPD FDKIVESLSL
LKDFFTSGHK LVSEVIGASD LLLLLGSPGE TAFRATDHGS ESDKHFRKGL LGELILLQQQ
IQEREEEARR AAGQYSTSYA QQKRKVSDKE KIDQLQEELL HTQLKYQRIL ERLEKENKEL
RKLVLQKDDK GIHHRKLKKS LIDMYSEVLD VLSDYDASYN TQDHLPRVVV VGDQSAGKTS
VLEMIAQARI FPRGSGEMMT RSPVKVTLSE GPHHVALFKD SSREFDLTKE EDLAALRHEI
ELRMRKNVKE GCTVSPETIS LNVKGPGLQR MVLVDLPGVI NTVTSGMAPD TKETIFSISK
AYMQNPNAII LCIQDGSVDA ERSIVTDLVS QMDPHGRRTI FVLTKVDLAE KNVASPSRIQ
QIIEGKLFPM KALGYFAVVT GKGNSSESIE AIREYEEEFF QNSKLLKTSM LKAHQVTTRN
LSLAVSDCFW KMVRESVEQQ ADSFKATRFN LETEWKNNYP RLRELDRNEL FEKAKNEILD
EVISLSQVTP KHWEEILQQS LWERVSTHVI ENIYLPAAQT MNSGTFNTTV DIKLKQWTDK
QLPNKAVEVA WETLQEEFSR FMTEPKGKEH DDIFDKLKEA VKEESIKRHK WNDFAEDSLR
VIQHNALEDR SISDKQQWDA AIYFMEEALQ ARLKDTENAI ENMVGPDWKK RWLYWKNRTQ
EQCVHNETKN ELEKMLKCNE EHPAYLASDE ITTVRKNLES RGVEVDPSLI KDTWHQVYRR
HFLKTALNHC NLCRRGFYYY QRHFVDSELE CNDVVLFWRI QRMLAITANT LRQQLTNTEV
RRLEKNVKEV LEDFAEDGEK KIKLLTGKRV QLAEDLSE
//