ID A0A2R9BDR9_PANPA Unreviewed; 923 AA.
AC A0A2R9BDR9;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=MutS homolog 4 {ECO:0000313|Ensembl:ENSPPAP00000027760.1};
GN Name=MSH4 {ECO:0000313|Ensembl:ENSPPAP00000027760.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000027760.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000027760.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000027760.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AJFE02107700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02107701; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02107702; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02107703; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9BDR9; -.
DR Ensembl; ENSPPAT00000050603.1; ENSPPAP00000027760.1; ENSPPAG00000036948.1.
DR GeneTree; ENSGT00550000074897; -.
DR Proteomes; UP000240080; Chromosome 1.
DR Bgee; ENSPPAG00000036948; Expressed in testis.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03243; ABC_MutS_homologs; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF21; MUTS PROTEIN HOMOLOG 4; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 741..757
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 103..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 923 AA; 103624 MW; DFDC5E489D173656 CRC64;
MLRPEISSTS PSAPAVSPSS GETRSPQGPR YNFGLQETPQ SRPSVQVVSA STPPGTSGAA
GDRSSSSSSL PCPAPNSRPA QGSYFGNKRA YAENTVASNF TFGASSSSAR DTNYPQTLKT
PLSTGNPQRS GYKSWTPQVG YSASSSSAIS AYSPSVIVAV VEGRGLARGE IGMASIDLKN
PQIILSQFAD NTTYAKVSIN NSRKCAWHFK LYFEIKTSFQ NVNFTTIQRK YFNETKGLEY
IEQLCIAEFS TVLMEVQSKY YCLAAVAALL KYVEFIQNSV YAPKSLKICF QGSEQTAMID
SSSAQNLELL INNQDCRNNH TLFGVLNYTK TPGGSRRLRS NILEPLVDIE TINMRLDCVQ
ELLQDEELFF GLQSVISRFL DTEQLLSVLV QIPKQDTVNA AESKITNLIY LKHTLELVDP
LKIAMKNCNT PLLRAYYGSL EDKRFGIILE KIKTVINDDA RYMKGCLNMR TQKCYAVRSN
INEFLDIARR TYTEIVDDIA GMISQLGEKY SLPLRTSFSS ARGFFIQMTT DCIALPTDQL
PSEFIKVSKV KNSYSFTSAD LIKMNERCQE SLREIYHMTY MIVCKLLSEI YEHIHCLYKL
SDTVSMLDML LSFAHACTLS DYVRPEFTDT LAIKQGWHPI LEKISAEKPI ANNTYITEGS
NFLIITGPNM SGKSTYLKQI ALCQIMAQIG SYVPAEYSSF RIAKQIFTRI STDDDIETNS
STFMKEMKEI AYILHNANDK SLILIDELGR GTNTEEGIGI CYAVCEYLLS LKAFTLFATH
FLELCHIDAL YPNVENMHFE VQHVKNTSRN KEAILYTYKL SKGLTEEKNY GLKAAEVSSL
PPSIVLDAKE ITTQITRQIL QNQRSTPEME RQRAVYHLAT RLVQTARNSQ LDPDSLRIYL
SNLKKKYKED FPRTEQVPEK TEE
//
