ID A0A2R9BGH4_PANPA Unreviewed; 2020 AA.
AC A0A2R9BGH4;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN Name=SCN5A {ECO:0000313|Ensembl:ENSPPAP00000027376.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000027376.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000027376.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000027376.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; AJFE02091553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02091554; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPPAT00000050216.1; ENSPPAP00000027376.1; ENSPPAG00000036665.1.
DR GeneTree; ENSGT00940000161691; -.
DR Proteomes; UP000240080; Chromosome 3.
DR Bgee; ENSPPAG00000036665; Expressed in heart.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR008053; Na_channel_a5su.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF206; SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR PRINTS; PR01666; NACHANNEL5.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 392..420
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 725..743
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 755..773
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 785..802
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 842..865
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 885..906
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 918..943
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1209..1228
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1249..1265
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1277..1298
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1326..1352
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1448..1474
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1533..1551
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1563..1585
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1597..1613
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1650..1678
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1753..1776
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 135..426
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 512..671
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 721..949
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 957..1204
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1208..1483
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1532..1786
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 28..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1009..1145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1963..2020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 417..455
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 484..507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1072
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1094..1122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1963..1998
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2020 AA; 227518 MW; 6D1B1AAA723DED27 CRC64;
MANFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSTTLQ ESREGLPEEE APRPQLDLQA
SKKLPDLYGN PPRELIGEPL EDLDPFYSNQ KTFIVLNKGK TIFRFSATNA LYVLSPFHPI
RRAAVKILLS LTPRTLFNML IMCTILTNCV FMAQHDPPPW TKYVEYTFTA IYTFESLVKI
LARGFCLHAF TFLRDPWNWL DFSVIIMAYT TEFVDLGNVS ALRTFRVLRA LKTISVISGL
KTIVGALIQS VKKLADVMVL TVFCLSVFAL IGLQLFMGNL RHKCVRNFTA LNGTNGSVEA
DGLVWESLDL YLSDPENYLL KNGTSDVLLC GNSSDAGTCP EGYRCLKAGE NPDHGYTSFD
SFAWAFLALF RLMTQDCWER LYQQTLRSAG KIYMIFFMLV IFLGSFYLVN LILAVVAMAY
EEQNQATIAE TEEKEKRFQE AMEMLKKEHE ALTIRGVDTV SRSSLEMSPL APVNSHERRS
KRRKRMSSGT EECGEDRLPK SDSEDGPRAM NHLSLTHGLS RTSMKPRSSR GSIFTFRRRD
LGSEADFADD ENSTAGESES HRTSLLVPWP LRRTSAQGQP SPGTSAPGHA LHGKKNSTVD
CNGVVSLLGA GDPEATSPGS HLLRPVMLEH PPDTTTPSEE PGGPQMLTSQ APCVDGFEEP
GARQRALSAV SVLTSALEEL EESRHKCPPC WNRLAQRYLI WECCPLWMSI KQGVKLVVMD
PFTDLTITMC IVLNTLFMAL EHYNMTSEFE EMLQVGNLVF TGIFTAEMTF KIIALDPYYY
FQQGWNIFDS IIVILSLMEL GLSRMSNLSV LRSFRLLRVF KLAKSWPTLN TLIKIIGNSV
GALGNLTLVL AIIVFIFAVV GMQLFGKNYS ELRDSDSGLL PRWHMMDFFH AFLIIFRILC
GEWIETMWDC MEVSGQSLCL LVFLLVMVIG NLVVLNLFLA LLLSSFSADN LTAPDEDREM
NNLQLALARI QRGLRFVKRT TWDFCCGLLR QRPQKPAALA AQGQLPSCIA TPYSPPPPET
EKAPPTRKET RFEEGEQPGQ GTPGDPEPVC VPIAVAESDT DDQEEDEENS LGTEEESSKQ
QESQPVSGGP EAPPDSRTWS QVSATASSEA EASASQADWR QQWKAEPQAP GCGETPEDSC
SEGSTADMTN TAELLEQIPD LGQDVKDPED CFTEGCVRRC PCCAVDTTQA PGKVWWRLRK
TCYHIVEHSW FETFIIFMIL LSSGALAFED IYLEERKTIK VLLEYADKMF TYVFVLEMLL
KWVAYGFKKY FTNAWCWLDF LIVDVSLVSL VANTLGFAEM GPIKSLRTLR ALRPLRALSR
FEGMRVVVNA LVGAIPSIMN VLLVCLIFWL IFSIMGVNLF AGKFGRCINQ TEGDLPLNYT
IVNNKSQCES LNMTGELYWT KVKVNFDNVG AGYLALLQVA TFKGWMDIMY AAVDSRGYEE
QPQWEYNLYM YIYFVIFIIF GSFFTLNLFI GVIIDNFNQQ KKKIRGQDIF MTEEQKKYYN
AMKKLGSKKP QKPIPRPLNK YQGFIFDIVT KQAFDVTIMF LICLNMVTMM VETDDQSPEK
INILAKINLL FVAIFTGECI VKLAALRHYY FTNSWNIFDF VVVILSIVGT VLSDIIQKYF
FSPTLFRVIR LARIGRILRL IRGAKGIRTL LFALMMSLPA LFNIGLLLFL VMFIYSIFGM
ANFAYVKWEA GIDDMFNFQT FANSMLCLFQ ITTSAGWDGL LSPILNTGPP YCDPTLPNSN
GSRGDCGSPA VGILFFTTYI IISFLIVVNM YIAIILENFS VATEESTEPL SEDDFDMFYE
IWEKFDPEAT QFIEYSVLSD FADALSEPLR IAKPNQISLI NMDLPMVSGD RIHCMDILFA
FTKRVLGESG EMDALKIQME EKFMAANPSK ISYEPITTTL RRKHEEVSAT VIQRAFRRHL
LQRSLKHASF LFRQQAGSGL SEEDAPEREG LIAYMMSENF SRPLGPPSSS SISSTSFPPS
YDSVTRATSD NLQVRGSDYS HSEDLADFPP SPDRDRESIV
//
