ID A0A2R9BH43_PANPA Unreviewed; 1470 AA.
AC A0A2R9BH43;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Myosin heavy chain 1 {ECO:0000313|Ensembl:ENSPPAP00000028979.1};
GN Name=MYH1 {ECO:0000313|Ensembl:ENSPPAP00000028979.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000028979.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000028979.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000028979.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Muscle contraction. {ECO:0000256|ARBA:ARBA00037488}.
CC -!- SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy
CC chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2
CC regulatory light chain subunits (MLC-2).
CC {ECO:0000256|ARBA:ARBA00038612}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; AJFE02061867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02061868; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPPAT00000051827.1; ENSPPAP00000028979.1; ENSPPAG00000037484.1.
DR GeneTree; ENSGT00940000154760; -.
DR OMA; CERMAKQ; -.
DR Proteomes; UP000240080; Chromosome 17.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:InterPro.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF2; MYOSIN-1; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Thick filament {ECO:0000256|ARBA:ARBA00022433}.
FT DOMAIN 1..313
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 190..212
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 377..1458
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1470 AA; 170136 MW; BBDCD9BFE715EB6E CRC64;
LIQGTHLEQL CINFTNEKLQ QFFNHHMFVL EQEEYKKEGI EWTFIDFGMD LAACIELIEK
PMGIFSILEE ECMFPKATDT SFKNKLYEQH LGKSNNFQKP KPAKGKPEAH FSLIHYAGTV
DYNIAGWLDK NKDPLNETVV GLYQKSAMKT LALLFAGATG AEAEAGGGKK GGKKKGSSFQ
TVSALFRENL NKLMTNLRST HPHFVRCIIP NETKTPGAME HELVLHQLRC NGVLEGIRIC
RKGFPSRILY ADFKQRYKVL NASAIPEGQF IDSKKASEKL LGSIDIDHTQ YKFGHTKVFF
KAGLLGLLEE MRDEKLAQLI TRTQAMCRGF LARVEYQKMV ERRESIFCIQ YNVRAFMNVK
HWPWMKLYFK IKPLLKSAET EKEMANMKEE FEKTKEELAK TEAKRKELEE KMVTLMQEKN
DLQLQVQAEA DSLADAEERC DQLIKTKIQL EAKIKEVTER AEDEEEINAE LTAKKRKLED
ECSELKKDID DLELTLAKVE KEKHATENKV KNLTEEMAGL DETIAKLTKE KKALQEAHQQ
TLDDLQAEED KVNTLTKAKI KLEQQVDDLE GSLEQEKKIR MDLERAKRKL EGDLKLAQES
TMDIENDKQQ LEEKLKKKEF EMSGLQSKIE DEQALGMQLQ KKIKELQARI EELEEEIEAE
RASRAKAEKQ RSDLSRELEE ISERLEEAGG ATSAQIEMNK KREAEFQKMR RDLEEATLQH
EATAATLRKK HADSVAELGE QIDNLQRVKQ KLEKEKSEMK MEIDDLASNM ETVSKAKGNL
EKMCRALEDQ LSEIKTKEEE QQRLINDLTA QRARLQTESG EYSRQLDEKD TLVSQLSRGK
QAFTQQIEEL KRQLEEEIKA KSALAHALQS SRHDCDLLRE QYEEEQEAKA ELQRAMSKAN
SEVAQWRTKY ETDAIQRTEE LEEAKKKLAQ RLQDAEEHVE AVNAKCASLE KTKQRLQNEV
EDLMIDVERT NAACAALDKK QRNFDKILAE WKQKCEETHA ELEASQKESR SLSTELFKIK
NAYEESLDQL ETLKRENKNL QQEISDLTEQ IAEGGKRIHE LEKIKKQVEQ EKSELQAALE
EAEASLEHEE GKILRIQLEL NQVKSEVDRK IAEKDEEIDQ MKRNHIRIVE SMQSTLDAEI
RSRNDAIRLK KKMEGDLNEM EIQLNHANRM AAEALRNYRN TQAILKDTQL HLDDALRSQE
DLKEQLAMVE RRANLLQAEI EELRATLEQT ERSRKIAEQE LLDASERVQL LHTQNTSLIN
TKKKLETDIS QIQGEMEDII QEARNAEEKA KKAITDAAMM AEELKKEQDT SAHLERMKKN
LEQTVKDLQH RLDEAEQLAL KGGKKQIQKL EARVRELEGE VESEQKRNVE AVKGLRKHER
KVKELTYQTE EDRKNILRLQ DLVDKLQAKV KSYKRQAEEA EEQSNVNLSK FRRIQHELEE
AEERADIAES QVNKLRVKSR EVHTKIISEE
//
