ID A0A2R9BK59_PANPA Unreviewed; 661 AA.
AC A0A2R9BK59;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=CD180 molecule {ECO:0000313|Ensembl:ENSPPAP00000029753.1};
GN Name=CD180 {ECO:0000313|Ensembl:ENSPPAP00000029753.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000029753.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000029753.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000029753.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AJFE02019161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02019162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02019163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003806843.1; XM_003806795.2.
DR AlphaFoldDB; A0A2R9BK59; -.
DR STRING; 9597.ENSPPAP00000029753; -.
DR Ensembl; ENSPPAT00000052604.1; ENSPPAP00000029753.1; ENSPPAG00000037903.1.
DR GeneID; 100995678; -.
DR KEGG; pps:100995678; -.
DR CTD; 4064; -.
DR GeneTree; ENSGT00940000161183; -.
DR OMA; MCTEKEA; -.
DR OrthoDB; 3038273at2759; -.
DR Proteomes; UP000240080; Chromosome 5.
DR Bgee; ENSPPAG00000037903; Expressed in prefrontal cortex and 3 other cell types or tissues.
DR GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0002322; P:B cell proliferation involved in immune response; IEA:Ensembl.
DR GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0031666; P:positive regulation of lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR041281; LRR_11.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24373:SF356; CD180 ANTIGEN; 1.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR Pfam; PF18831; LRR_11; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..661
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015352777"
FT TRANSMEM 627..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 577..626
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
SQ SEQUENCE 661 AA; 74126 MW; F4AAC9648F981B54 CRC64;
MAFDVSCFFW VVLFSAGCKV ITSWDQMCIE KEANKTYNCE NLGLSEIPDT LPNTTEFLEF
SFNFLPTIHN RTFSRLMNLT FLDLTRCQIN WIHEDTFQSH HQLSTLVLTG NPLIFMAETS
LNGPKSLKHL FLIQTGISNL EFIPVHNLEN LESLYLGSNH ISSIKFPKDF PAQNLKVLDF
QNNAIHYISR EDMRSLEQAI NLSLNFNGNN VKGIELGAFD STVFQSLNFG GTPNLSVIFN
GLQNSTTQSL WLGTFEDIDD EDISSAMLKG LCEMSVESLN LQEHRFSDIS STTFQCFTQL
QELDLTATHL KGLPSGIKGL NLLKKLVLSV NHFDQLCQIS AANFPSLTHL YIRGNVKKLH
LGVGCLEKLG NLETLDLSHN DIEASDCCSL QLKNLSHLQT LNLSHNEPLG LQSQAFKECP
QLELLDLAFT RLHINAPQSP FQNLHFLQVL NLTYCFLDTS NQHLLAGLPV LRHLNLKGNH
FQDGTITKTS LLQTVGSLEV LILSSCGLLS IDQQAFHSLG KMSRVDLSHN SLTCDSIDSL
SHLKGIYLNL AANSINIISP RLLPILSQQS TINLSHNPLD CTCSNIHFLT WYKENLHKLE
GSEETTCANP PSLRGVKLSD VKLSCGITAI GIFFLILFLL LLAILLFFAV KYLLRWKYQH
I
//
