ID A0A2R9BK87_PANPA Unreviewed; 548 AA.
AC A0A2R9BK87;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Homeobox and leucine zipper encoding {ECO:0000313|Ensembl:ENSPPAP00000029788.1};
GN Name=HOMEZ {ECO:0000313|Ensembl:ENSPPAP00000029788.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000029788.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000029788.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000029788.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
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DR EMBL; AJFE02024199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02024200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003808144.1; XM_003808096.2.
DR AlphaFoldDB; A0A2R9BK87; -.
DR STRING; 9597.ENSPPAP00000029788; -.
DR Ensembl; ENSPPAT00000052639.1; ENSPPAP00000029788.1; ENSPPAG00000037914.1.
DR GeneID; 100981693; -.
DR KEGG; pps:100981693; -.
DR CTD; 57594; -.
DR GeneTree; ENSGT00950000182893; -.
DR OMA; RYWATHQ; -.
DR OrthoDB; 4218493at2759; -.
DR Proteomes; UP000240080; Chromosome 14.
DR Bgee; ENSPPAG00000037914; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd00086; homeodomain; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 3.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR024578; Homez_homeobox_dom.
DR PANTHER; PTHR15467:SF7; HOMEOBOX AND LEUCINE ZIPPER PROTEIN HOMEZ; 1.
DR PANTHER; PTHR15467; ZINC-FINGERS AND HOMEOBOXES RELATED; 1.
DR Pfam; PF11569; Homez; 1.
DR SMART; SM00389; HOX; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS50071; HOMEOBOX_2; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 70..109
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 354..414
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 72..110
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 356..415
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..465
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 548 AA; 61009 MW; 94257878B0AEB620 CRC64;
MVRGWEPPPG LDCAISEGHK SESTMPPNKE ASGLSSSPAG LICLPPISEE LQLVWTQAAQ
TSELDSNEHL LKTFSYFPYP SLADIALLCL RYGLQMEKVK TWFMAQRLRC GISWSSEEIE
ETRARVVYRR DQLHFKSLLS FTHHAGRPPE EVPPPPMPAP EQVGIGIGPP TLSKPTQTKG
LKVEPEESSQ MPPLPQSHQK LKESLMTPGS GAFPHQSDFW QHLQSSGLSK EQAGRGPSQS
HGIGTASWNH STTVPQPQAR DKPPPIALIA SSCKEESASS VTPSSSSTSS SFQVLANGAT
AASKPLQPLG CVPQSVSPSE QALPPHLEPA WPQGLRHNSI PGRVGPTEYL SPDMQRQRKT
KRKTKEQLAI LKSFFLQCQW ARREDYQKLE QITGLPRPEI IQWFGDTRYA LKHGQLKWFR
DNAVPGAPSF QDPAIPTPPP STRSLNERAE TPPLPIPPPP PDIQPLERYW AAHQQLRETD
IPQLSQASRL STQQVLDWFD SRLPQPAEVV VCLDEEEEEE EEELPEDDEE EEEEEEDDDD
DDDVIIQD
//
