ID A0A2R9BKL8_PANPA Unreviewed; 865 AA.
AC A0A2R9BKL8;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Synaptosome associated protein 91 {ECO:0000313|Ensembl:ENSPPAP00000028912.1};
GN Name=SNAP91 {ECO:0000313|Ensembl:ENSPPAP00000028912.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000028912.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000028912.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000028912.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PICALM/SNAP91 family.
CC {ECO:0000256|ARBA:ARBA00008011}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00243}.
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DR EMBL; AJFE02055669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02055670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02055671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9BKL8; -.
DR Ensembl; ENSPPAT00000051760.1; ENSPPAP00000028912.1; ENSPPAG00000037215.1.
DR GeneTree; ENSGT00950000183068; -.
DR Proteomes; UP000240080; Chromosome 6.
DR Bgee; ENSPPAG00000037215; Expressed in cerebellum and 3 other cell types or tissues.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0048268; P:clathrin coat assembly; IEA:InterPro.
DR GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
DR CDD; cd16985; ANTH_N_AP180; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 1.20.58.150; ANTH domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR014712; ANTH_dom_sf.
DR InterPro; IPR045192; AP180-like.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR PANTHER; PTHR22951; CLATHRIN ASSEMBLY PROTEIN; 1.
DR PANTHER; PTHR22951:SF4; CLATHRIN COAT ASSEMBLY PROTEIN AP180; 1.
DR Pfam; PF07651; ANTH; 1.
DR SMART; SM00273; ENTH; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50942; ENTH; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|PROSITE-ProRule:PRU00243};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00243};
KW Transmembrane helix {ECO:0000256|PROSITE-ProRule:PRU00243}.
FT TRANSMEM 348..369
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00243"
FT DOMAIN 14..145
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT REGION 285..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 865 AA; 89271 MW; 05D1399495D2A49C CRC64;
MSGQTLTDRI AAAQYSVTGS AVARAVCKAT THEVMGPKKK HLDYLIQATN ETNVNIPQMA
DTLFERATNS SWVVVFKALV TTHHLMVHGN ERFIQYLASR NTLFNLSNFL DKSGSHGYDM
STFIRRYSRY LNEKAFSYRQ MAFDFARVKK GADGVMRTMA PEKLLKSMPI LQGQIDALLE
FDVHPNELTN GVINAAFMLL FKDLIKLFAC YNDGVINLLE KFFEMKKGQC KDALEIYKRF
LTRMTRVSEF LKVAEQVGID KGDIPDLTQA PSSLMETLEQ HLNTLEGKKP GNKSGAPSPL
SKSSPATTVT SPNSTPAKTI DTSPPVDLFA TASAAVPVRL VNKYAVNFWY IFCLLLFFSL
FALYSLAALS SVPSEAQISD PFAPEPTPPT TTAEIATASA SASTTTTVTA VTAEVDLFGD
AFAASPGEAP AASEGAAAPA TPTPVAAALD ACSGNDPFAP SEGSAEAAPE LDLFAMKPPE
TSVPVVTPTA STAPPVPATA PSPAPAVAAA AAATTAATAA ATTTTTTSAA TATTAPPALD
IFGGNFLLLL STSFHAFSSP PQGASPVPES SLTADLLSVD AFAAPSPATT ASPAKVDSSG
VIDLFGDAFG SSASEPQPAS QAASSSSASA DLLAGFGGSF MAPSPSPVTP AQNNLLQPNF
EAAFGTTPST SSSSSFDPSG DLLMPTMAPA GQPAPVSMVP PSPAMAASKA LGSDLDSSLA
SLVGNLGISG TTTKKGDLQW NAGEKKLTGG ANWQPKVAPA TWSAGVPPSA PLQGAVPPTS
SVPPVAGAPS VGQPGAGFGM PPAGTGMPMM PQQPVMFAQP MMRPPFGAAA VPGTQLSPSP
TPASQSPKKP PAKDPLADLN IKDFL
//
