ID A0A2R9BNN9_PANPA Unreviewed; 1742 AA.
AC A0A2R9BNN9;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Laminin subunit beta 4 {ECO:0000313|Ensembl:ENSPPAP00000031276.1};
GN Name=LAMB4 {ECO:0000313|Ensembl:ENSPPAP00000031276.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000031276.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000031276.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000031276.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR EMBL; AJFE02035110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02035111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02035112; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPPAT00000054141.1; ENSPPAP00000031276.1; ENSPPAG00000038537.1.
DR GeneTree; ENSGT00940000162514; -.
DR OMA; RRCSCHP; -.
DR Proteomes; UP000240080; Chromosome 7.
DR Bgee; ENSPPAG00000038537; Expressed in testis and 1 other cell type or tissue.
DR CDD; cd22301; cc_LAMB4_C; 1.
DR CDD; cd00055; EGF_Lam; 12.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 11.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR013015; Laminin_IV_B.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF435; LAMININ SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 12.
DR Pfam; PF21199; LAMININ_IV_B; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00180; EGF_Lam; 13.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR PROSITE; PS01248; EGF_LAM_1; 3.
DR PROSITE; PS50027; EGF_LAM_2; 10.
DR PROSITE; PS51116; LAMININ_IVB; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 20..260
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 261..327
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 328..390
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 391..445
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 450..500
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 540..758
FT /note="Laminin IV type B"
FT /evidence="ECO:0000259|PROSITE:PS51116"
FT DOMAIN 764..811
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 812..857
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 858..905
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 965..1016
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1017..1074
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1109..1155
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT COILED 1249..1276
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1403..1458
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1506..1660
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1695..1736
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 293..302
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 358..367
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 421..430
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 472..481
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 484..498
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 764..776
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 766..783
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 785..794
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 812..824
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 814..831
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 833..842
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 889..903
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 989..998
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1047..1056
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1109..1121
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1111..1128
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1130..1139
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1742 AA; 191490 MW; 8B95B5861E36880B CRC64;
LYFCCVQGWL SYSKAQDDCN RGACHPTTGD LLVGRNMQLT ASSTCGLSRA QKYCILSYLE
GEQKCFICDS RFPYDPYDQP NSHTIENVIV SFEPDREKKW WQSENGLDRV SIRLDLEALF
RFSHLILTFK TFRPAAMLVE RSTDYGHNWK VFKYFAKDCA TSFPNITSGQ AQGVGDIVCD
SKYSDIEPST GGEVVLKVLD PSFEIENPYS PYIQDLVTLT NLRINFTKLH TLGDTLLGRR
QNDSLDKYYY ALYEMIVRGS CFCNGHASEC RPMQKMRGDV FSPPGMVHGQ CVCQHNTDGP
NCERCKDFFQ DAPWRPAADL QDNACRSCSC NSHSSRCHFD MTTYLASGGL SGGVCEDCQH
NTEGQHCDRC RPLFYRDPLK TISDPYACIP CECDPDGTIS GGICVSHSDP ALGSVAGQCL
CKENVEGAKC DQCKPNHYGL SATDPWAATC DCNPPGSLPF LTCDVDTGQC LCLSYVTGAH
CEECTVGYWG LGNHLHGCSP CDCDIGGAYS NVCSPKNGQC ECRPHVTGRS CSEPAPGYFF
APLNFYLYEA EEATPLQGLA PLGSETFGQS PAVHVVLGEP VPGNPVTWSG PGFARVLPGA
GLRFAVNNIP FPVDFTIAIR YETQSAADWT VQIVVNPPGG SKHCIPKTLQ SKPQSFALPA
ATRIMLLPTP ICLEPDVQYS IDVYFSQPLQ GESHAHSHVL VDSLGLIPQI NSLENFCSKQ
DLDEYQLHNC VEIASAMGPQ VLPAACERLI ISMSAKLHDG AVACKCHPQG SVGSSCSRLG
GQCQCKPLVV GRCCDRCSTG SYDLGHHGCH PCHCHPQGSK DTVCDQVTGQ CPCHGEVSGR
RCDRCLAGYF GFPSCHPCPC NGFAELCDPE TGSCFNCGGF TTGRNSERCI DGYYGNPSSG
QPCRPCLCPD DPSSNQYFAH SCYQNLWSSD VICNCLQGYT GTQCGECSTG FYGNPRISGA
PCRPCACNNN IDVTDPESCS RVTGECLRCL HNTQGANCQL CKPGHYGSAF NQTCRRCSCH
ASGVSPMECP PGGGACLCDP VTGACPCLPN VTGLACDRCA DGYWNLVPGR GCQSCDCDPR
TSQSSHCDQL TGQCPCKLGY GGKRCSESCD CNRAGTQKPI CDPDTGMCRC REGVSGQRCD
RCARGHSQEF PTCLQCHLCF DQWDHTISSL SKAVQGLMRL AANMEDKRET LPVCEADFKD
LRGNVSEIER ILKHPVFPSG KFLKVKDYHD SVRKQIMQLN EQLKAVYEFQ DLKDTIERAK
NEADLLLEDL QEEIDLQSSV LNASIVDSSE NIKKYYHISS SAEKKINETS STINTSANTR
NDLLTILDTL TSKGNLSLER LKQIKIPDIQ ILNEKVCRDP GNVPCVPLPC GGALCTGRKG
HRKCRGPGCH GSLTLSTNAL QKAQEAKSII RNLDKQVRGL KNQIESISER AEVSKNNALQ
LREKLGNIRN QSDSEEENIN LFIKKVKNFL LEENVPPEDI EKVANGVLDI HLPIPSQNLT
DELDKIQKHM QLCEDYRTDE NRLNEEADGA QKLLVKAKAA EKEANILLNL DKTLNQLQQA
QITQGWANST ITQLTANVTK IKKNVLQAEN QTREMKSELE LAKQRSGLED GLSLLQTKLQ
SHQDHAVNAK VQAESAQHQA GSLEKEFVEL KKQYAILQRK TSTTGLTKET LGKVKQLKDA
AEKLAGDTEA KIRRITDLER KIQDLNLSRQ AKADQLRILE DQVVAIKNEI VEQEKKYARC
YS
//
