ID A0A2R9BPE7_PANPA Unreviewed; 514 AA.
AC A0A2R9BPE7;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Cytochrome P450 family 24 subfamily A member 1 {ECO:0000313|Ensembl:ENSPPAP00000031540.1};
GN Name=CYP24A1 {ECO:0000313|VGNC:VGNC:83045};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000031540.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000031540.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000031540.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; AJFE02096909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003827565.1; XM_003827517.2.
DR AlphaFoldDB; A0A2R9BPE7; -.
DR STRING; 9597.ENSPPAP00000031540; -.
DR Ensembl; ENSPPAT00000054405.1; ENSPPAP00000031540.1; ENSPPAG00000038708.1.
DR VGNC; VGNC:83045; CYP24A1.
DR GeneTree; ENSGT00950000182905; -.
DR OMA; VLMINTH; -.
DR OrthoDB; 2658719at2759; -.
DR Proteomes; UP000240080; Chromosome 20.
DR Bgee; ENSPPAG00000038708; Expressed in adult mammalian kidney and 1 other cell type or tissue.
DR GO; GO:0062181; F:1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity; IEA:Ensembl.
DR GO; GO:0030342; F:1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; IEA:Ensembl.
DR GO; GO:0062180; F:25-hydroxycholecalciferol-23-hydroxylase activity; IEA:Ensembl.
DR GO; GO:0008403; F:25-hydroxycholecalciferol-24-hydroxylase activity; IEA:Ensembl.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0070643; F:vitamin D 25-hydroxylase activity; IEA:Ensembl.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0033280; P:response to vitamin D; IEA:Ensembl.
DR GO; GO:0042369; P:vitamin D catabolic process; IEA:Ensembl.
DR CDD; cd20645; CYP24A1; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24279; -; 1.
DR PANTHER; PTHR24279:SF120; CYTOCHROME P450 FAMILY 24 SUBFAMILY A MEMBER 1; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
SQ SEQUENCE 514 AA; 59017 MW; D09BB3830F49B5E3 CRC64;
MSSPISKSRS LAAFLQQLRS PRQPPRLVTS TAYTSPQPRE VPVCPLTTGG ETQNAAALPG
PTRWPLLGSL LQILWKGGLK KQHDTLVEYH KKYGKIFRMK LGSFESVHLG SPCLLEALYR
TESAYPQRLE IKPWKAYRDY REEGYGLLIL EGEDWQRVRS AFQKKLMKPG EVMKLDNKIN
EVLADFMGRI DELCDERGHI EDLYSELNKW SFESICLVLY EKRFGLLQKN AGDEAVNFIM
AIKTMMSTFG RMMVTPVELH KSLNTKVWQD HTLAWDTIFK SVKACIDNRL EKYSQQPSAD
FLCDIYHQNR LSKKELYAAV TELQLAAVET TANSLMWILY NLSRNPQVQQ KLLKEIQSVL
PENQVPRAED LRNMPYLKAC LKESMRLTPS IPFTTRTLDK ATVLGEYALP KGTVLMLNTQ
VLGSSEDNFE DSSQFRPERW LQEKEKINPF AHLPFGIGKR MCIGRRLAEL QLHLALCWIV
RKYDIQATDN EPVEMLHSGT LVPSRELPIA FCQR
//
