ID A0A2R9BPZ7_PANPA Unreviewed; 1102 AA.
AC A0A2R9BPZ7;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A10 {ECO:0000313|Ensembl:ENSPPAP00000031494.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000031494.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000031494.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362035}.
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DR EMBL; AJFE02071945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02071946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9BPZ7; -.
DR Ensembl; ENSPPAT00000054359.1; ENSPPAP00000031494.1; ENSPPAG00000037470.1.
DR GeneTree; ENSGT00940000156972; -.
DR Proteomes; UP000240080; Unplaced.
DR Bgee; ENSPPAG00000037470; Expressed in cerebellum and 3 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022853; F:active monoatomic ion transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0015106; F:bicarbonate transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR GO; GO:0098660; P:inorganic ion transmembrane transport; IEA:UniProt.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF32; SODIUM-DRIVEN CHLORIDE BICARBONATE EXCHANGER; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 494..516
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 581..604
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 611..629
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 709..727
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 747..765
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 795..814
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 835..859
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 895..917
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 990..1007
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 130..418
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 465..973
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 42..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..59
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1102 AA; 124194 MW; 9BE4072BA22596FD CRC64;
ENDEEAVVDR GGTRSILKTH FEKEDLEGHR TLFIGVHVPL GGRKSHRRHR HRGHKHRKRD
RERDSGLEDG RESPSFDTPS QRVQFILGTE DDDEEHIPHD LFTELDEICW REGEDAEWRE
TARWLKFEED VEDGGERWSK PYVATLSLHS LFELRSCILN GTVLLDMHAN TLEEIADMVL
DQQVSSGQLN EDVRHRVHEA LMKQHHHQNQ KKLTNRIPIV RSFADIGKKQ SEPNSMDKNA
GQVVSPQSAP ACVENKNDVS RENSTVDFSK GLGGQQKGHT SPCGMKQRHE KGPPHQQERE
VDLHFMKKIP PGAEASNILV GELEFLDRTV VAFVRLSPAV LLQGLAEVPI PTRFLFILLG
PLGKGQQYHE IGRSIATLMT DEVFHDVAYK AKDRNDLVSG IDEFLDQVTV LPPGEWDPSI
RIEPPKNVPS QEKRKIPAVP NGTAAHGEAE PHGGHSGPEL QRTGRIFGGL ILDIKRKAPY
FWSDFRDAFS LQCLASFLFL YCACMSPVIT FGGLLGEATE GRISAIESLF GASMTGIAYS
LFGGQPLTIL GSTGPVLVFE KILFKFCKEY GLSYLSLRAS IGLWTATLCI ILVATDASSL
VCYITRFTEE AFASLICIIF IYEALEKLFE LSEAYPINMH NDLELLTQYS CNCVEPHNPS
NDTLKEWRES NISASDIIWE NLTVSECKSL HGEYVGRACG HDHPYVPDVL FWSVILFFST
VTLSATLKQF KTSRYFPTKV RSIVSDFAVF LTILCMVLID YAIGIPSPKL QVPSVFKPTR
DDRGWFVTPL GPNPWWTVIA AIIPALLCTI LIFMDQQITA VIINRKEHKL KKGCGYHLDL
LMVAVMLGVC SIMGLPWFVA ATVLSITHVN SLKLESECSA PGEQPKFLGI REQRVTGLMI
FILMGSSVFM TSILKFIPMP VLYGVFLYMG ASSLKGIQFF DRIKLFWMPA KHQPDFIYLR
HVPLRKVHLF TIIQMSCLGL LWIIKVSRAA IVFPMMVLAL VFVRKLMDLL FTKRELSWLD
DLMPESKKKK LEDAEKEEEQ SMLAMEDEGT VQLPLEGHYR DDPSVINISD EMSKTALWRN
LLITADNSKD KESSFPSKSS PS
//
