ID   A0A2R9BQC3_PANPA        Unreviewed;       661 AA.
AC   A0A2R9BQC3;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=RAP1 GTPase activating protein {ECO:0000313|Ensembl:ENSPPAP00000028836.1};
GN   Name=RAP1GAP {ECO:0000313|Ensembl:ENSPPAP00000028836.1};
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000028836.1, ECO:0000313|Proteomes:UP000240080};
RN   [1] {ECO:0000313|Ensembl:ENSPPAP00000028836.1, ECO:0000313|Proteomes:UP000240080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22722832; DOI=10.1038/nature11128;
RA   Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA   Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA   Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA   Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA   Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA   Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA   Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA   Paabo S.;
RT   "The bonobo genome compared with the chimpanzee and human genomes.";
RL   Nature 486:527-531(2012).
RN   [2] {ECO:0000313|Ensembl:ENSPPAP00000028836.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJFE02044669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02044670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02044671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02044672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02044673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2R9BQC3; -.
DR   Ensembl; ENSPPAT00000051684.1; ENSPPAP00000028836.1; ENSPPAG00000037273.1.
DR   GeneTree; ENSGT00940000156138; -.
DR   OMA; XESVSSS; -.
DR   Proteomes; UP000240080; Chromosome 1.
DR   Bgee; ENSPPAG00000037273; Expressed in prefrontal cortex and 6 other cell types or tissues.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 6.10.140.210; -; 1.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR15711:SF3; RAP1 GTPASE-ACTIVATING PROTEIN 1; 1.
DR   Pfam; PF21022; Rap-GAP_dimer; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW   ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT   DOMAIN          179..395
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   REGION          440..602
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          614..643
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        440..463
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        520..552
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        561..576
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   661 AA;  72735 MW;  AD8C0D5D512E4B55 CRC64;
     GGECCLLLQG SRMDEQRCSF PPPLKVGGPV PLQVLGREGP FPLILLPQFG GYWIEGTNHE
     ITSIPETEPL QSPTTKVKLE CNPTARIYRK HFLGKEHFNY YSLDTALGHL VFSLKYDVIG
     DQEHLRLLLR TKCRTYHDVI PISCLTEFPN VVQMAKLVCE DVNVDRFYPV LYPKASRLIV
     TFDEHVISNN FKFGVIYQKL GQTSEEELFS TNEESPAFVE FLEFLGQKVK LQDFKGFRGG
     LDVTHGQTGT ESVYCNFRNK EIMFHVSTKL PYTEGDAQQL QRKRHIGNDI VAVVFQDENT
     PFVPDMIASN FLHAYVVVQA EGGGPDGPLY KVSVTARDDV PFFGPPLPDP AVFRKGPEFQ
     EFLLTKLINA EYACYKAEKF AKLEERTRAA LLETLYEELH IHSQSMMGLG GDEDKMENGS
     GGGGFFESFK RVIRSRSQSM DAMGLSNKKP NTVSTSHSGS FAPNNPDLAK AAGISLIVPG
     KSPTRKKSGP FGSRRSSAIG IENIQEVQEK RESPPAGQKT PDSGHVSQEP KSENSSTQSS
     PEMPTTKNRA ETAAQRAEAL KDFSRSSSSA SSFASVVEET EGVDGEDTGL ESVSSSGTPH
     KRDSFIYSTW LEDSVSTTSG GSSPGPSRSP HPDAGKLGDP ACPEIKIQLE ASEQHMPQLG
     C
//