ID A0A2R9BQL9_PANPA Unreviewed; 1724 AA.
AC A0A2R9BQL9;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Eukaryotic translation initiation factor 4 gamma 3 {ECO:0000313|Ensembl:ENSPPAP00000031966.1};
GN Name=EIF4G3 {ECO:0000313|Ensembl:ENSPPAP00000031966.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000031966.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000031966.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000031966.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC {ECO:0000256|ARBA:ARBA00005775}.
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DR EMBL; AJFE02046447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046456; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9597.ENSPPAP00000031966; -.
DR Ensembl; ENSPPAT00000054832.1; ENSPPAP00000031966.1; ENSPPAG00000038299.1.
DR GeneTree; ENSGT00940000156454; -.
DR Proteomes; UP000240080; Chromosome 1.
DR Bgee; ENSPPAG00000038299; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd11559; W2_eIF4G1_like; 1.
DR Gene3D; 1.25.40.180; -; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045208; IF4G.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR PANTHER; PTHR23253:SF23; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 3; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS51366; MI; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 1360..1482
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT DOMAIN 1555..1724
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 645..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 999..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1156..1181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1211..1353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..327
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1225..1266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1327..1341
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1724 AA; 191131 MW; 4B7874137220B059 CRC64;
VKKIHRHRLS PATEKGAASS GEGDKDPPPP AHEAPPHPNI RALQTQAPQQ IPRGPVQQPL
EDRIFTPAVS AVYSTVTQVA RQPGTPTTSP YSAHEINKGH PNLAATPPGH ASSPGLSQTP
YPSGQNAGPT TLVYPQAPQT MNSQPQTRSP FFQRPQIQPP RATIPNSSPS IRPGAQTPTA
VYQANQHIMM VNHLPMPYPV PQGPQYCIPQ YRHSGPPYVG PPQQYPVQPP GPGPFYPGPG
PGDFPNAYGT PFYPSQPVYQ SAPIIVPTQQ QPPPAKREKK TIRIRDPNQG GKDITEEIMS
GGGSRNPTPP IGRPTSTPTP PQLPSQVPEH SPVVYGTVES AHLAASTPVT AASDQKQEEK
PKPDPVLKSP SPVLRLVLSG EKKEQEGQTS ETTAIVSIAE LPLPPSPTTV SSVARSTIAA
PTSSALSSQP IFTTAIDDRC ELSSPREDTI PIPSLTSCTE TSDPLPTNEN DDDICKKPCS
VAPNDIPLVS STNLINEING VSEKLSATES IVEIVKQEVL PLTLELEILE NPPEEMKLEC
IPAPITPSTV PSFPPTPPTP PASPPHTPVI VPAAATTVSS PSAAITVQRV LEEDESIRTC
LSEDAKEIQN KIEVEADGQT EEILDSQNLN SRRSPVPAQI AITVPKTWKK PKDRTRTTEE
MLEAELEPKA EEELSVDKVL ESEQDKMSQG FHPERDPSDL KKVKAVEENG EEAEPVRNGA
ESVSEGEGID ANSGSTDSSG DGVTFPFKPE SWKPTDTEGK KQYDREFLLD FQFMPACIQK
PEGLPPISDV VLDKINQPKL PMRTLDPRIL PRGPDFTPAF ADFGRQTPGG RGVPLLNVGS
RRSQPGQRRE PRKIITVSVK EDVHLKKAEN AWKPSQKRDS QADDPENIKT QELFRKVRSI
LNKLTPQMFN QLMKQVSGLT VDTEERLKGV IDLVFEKAID EPSFSVAYAN MCRCLVTLKV
PMADKPGNTV NFRKLLLNRC QKEFEKDKAD DDVFEKKQKE LEAASAPEER TRLHDELEEA
KDKARRRSIG NIKFIGELFK LKMLTEAIMH DCVVKLLKNH DEESLECLCR LLTTIGKDLD
FEKAKPRMDQ YFNQMEKIVK ERKTSSRIRF MLQDVIDLRL CNWVSRRADQ GPKTIEQIHK
EAKIEEQEEQ RKVQQLMTKE KRRPGVQRVD EGGWNTVQGA KNSRVLDPSK FLKITKPTID
EKIQLVPKAQ LGSWGKGSSG GAKASETDAL RSSASSLNRF SALQPPAPSG STPSTPVEFD
SRRTLTSRGS MGREKNDKPL PSATARPNTF MRGGSSKDLL DNQSQEEQRR EMLETVKQLT
GGVDVERNST EAERNKTRES AKPEISAVSA HDKAALSEEE LERKSKSIID EFLHINDFKE
AMQCVEELNA QGLLHVFVRV GVESTLERSQ ITRDHMGQLL YQLVQSEKLS KQDFFKGFSE
TLELADDMAI DIPHIWLYLA ELVTPMLKEG GISMRELTIE FSKPLLPVGR AGVLLSEILH
LLCKQMSHKK VGALWREADL SWKDFLPEGE DVHNFLLEQK LDFIESDSPC SSEALSKKEL
SAEELYKRLE KLIIEDKAND EQIFDWVEAN LDEIQMSSPT FLRALMTAVC KAAIIADSST
FRVDTAVIKQ RVPILLKYLD SDTEKELQAL YALQASIVKL DQPANLLRMF FDCLYDEEVI
SEDAFYKWES SKDPAEQNGK GVALKSVTAF FTWLREAEEE SEDN
//
