ID A0A2R9BT31_PANPA Unreviewed; 810 AA.
AC A0A2R9BT31;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Epidermal growth factor receptor pathway substrate 8 {ECO:0000313|Ensembl:ENSPPAP00000032616.1};
GN Name=EPS8 {ECO:0000313|Ensembl:ENSPPAP00000032616.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000032616.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000032616.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000032616.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the EPS8 family.
CC {ECO:0000256|ARBA:ARBA00006197}.
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DR EMBL; AJFE02056085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9BT31; -.
DR Ensembl; ENSPPAT00000055485.1; ENSPPAP00000032616.1; ENSPPAG00000039147.1.
DR GeneTree; ENSGT00940000156403; -.
DR Proteomes; UP000240080; Chromosome 12.
DR Bgee; ENSPPAG00000039147; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR CDD; cd01210; PTB_EPS8; 1.
DR CDD; cd09540; SAM_EPS8-like; 1.
DR CDD; cd11764; SH3_Eps8; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR039801; EPS8-like.
DR InterPro; IPR033928; EPS8_PTB.
DR InterPro; IPR035462; Eps8_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041418; SAM_3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12287:SF21; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8; 1.
DR PANTHER; PTHR12287; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF18016; SAM_3; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 519..578
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 190..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..208
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..634
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..656
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..677
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 810 AA; 90492 MW; 5FCB5E5A478D32AC CRC64;
MNGHISNHPS SFGMYPSQMN GYGSSPTFSQ MDREHGSKTS AKALYGRFVY LIGCNFHLTT
FVLDRKDAMI TVDDGIRKLK LLDAKGKVWT QDMILQVDDR AVSLIDLESK NELENFPLNT
IQHCQAVMHS CSYDSVLALV CKEPTQNKPD LHLFQCDEVK ANLISEDIES AISDSKGGKQ
KRRPDALRMI SNADPSIPPP PRAPAPAPPG TVTQVDVRSR VAAWSAWAAD QGDFEKPRQY
HEQEETPEMM AARIDRDVQI LNHILDDIEF FITKLQKAAE AFSELSKRKK NKKGKRKGPG
EGVLTLRAKP PPPDEFLDCF QKFKHGFNLL AKLKSHIQNP SAADLVHFLF TPLNMVVQAT
GGPELASSVL SPLLNKDTID FLNYTVNGDE RQLWMSLGGT WMKARAEWPK EHFIPPYVPR
FRNGWEPPML NFMGATMEQD LYQLAESVAN VAEHQRKQEI KRLSTEHSSV SEYHPADGYA
FSSNIYTRGS HLDQGEAAVA FKPTSNRHID RNYEPLKTQP KKYAKSKYDF VARNNSELSV
LKDDILEILD DRKQWWKVRN ASGDSGFVPN NILDIVRPPE SGLGRADPPY THTIQKQRME
YGPRPADTPP APSPPPTPAP VPVPLPPSTP APVPVSKVPA NITRQNSSSS DSGGSIVRDS
QRHKQLPVDR RKSQMEEVQD ELIHRLTIGR SAAQKKFHVP RQNVPVINIT YDSTPEDVKT
WLQSKGFNPV TVNSLGVLNG AQLFSLNKDE LRTVCPEGAR VYSQITVQKA ALEDSSGSSE
LQEIMRRRQE KISAAASDSG VESFDEGSSH
//
