ID A0A2R9BV73_PANPA Unreviewed; 413 AA.
AC A0A2R9BV73;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
GN Name=HS3ST4 {ECO:0000313|Ensembl:ENSPPAP00000033361.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000033361.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000033361.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000033361.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC {ECO:0000256|RuleBase:RU361155}.
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DR EMBL; AJFE02022869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02022870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02022871; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02022872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02022873; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02022874; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02022875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02022876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02022877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02022878; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9BV73; -.
DR STRING; 9597.ENSPPAP00000033361; -.
DR Ensembl; ENSPPAT00000056236.1; ENSPPAP00000033361.1; ENSPPAG00000039544.1.
DR GeneTree; ENSGT00940000161466; -.
DR OMA; GARDAWP; -.
DR Proteomes; UP000240080; Chromosome 16.
DR Bgee; ENSPPAG00000039544; Expressed in prefrontal cortex and 1 other cell type or tissue.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF11; HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 4; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transferase {ECO:0000256|RuleBase:RU361155}.
FT DOMAIN 155..390
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT REGION 25..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..76
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 164
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 164..168
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 245
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 253
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 370..374
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 353..365
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 413 AA; 45546 MW; 9C74D90F40F4EF66 CRC64;
LSVTYLCYSL LGGSGSLQFP LALQESPGAA AEPPPSPPPP SLLPPPVRLG APSQPPAPPP
LDNASHGEPP ESPEQPAAPG TDGWLPSGGG GARDAWLRTP LAPSEMITAQ SALPEREAQE
SSTTDEDLAG RRAANGSSER GGAVSTPDYG EKKLPQALII GVKKGGTRAL LEAIRVHPDV
RAVGVEPHFF DRNYEKGLEW YRNVMPKTLD GQITMEKTPS YFVTNEAPKR IHSMAKDIKL
IVVVRNPVTR AISDYTQTLS KKPEIPTFEV LAFKNRTLGL IDASWSAIRI GIYALHLENW
LQYFPLSQIL FVSGERLIVD PAGEMAKVQD FLGLKRVVTE KHFYFNKTKG FPCLKKPEDS
STPRCLGKSK GRTHPRIDPD VIHRLRKFYK PFNMMFYQMT GQDFQWEQEE GDK
//
