ID A0A2R9BVD4_PANPA Unreviewed; 343 AA.
AC A0A2R9BVD4;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Apolipoprotein L6 {ECO:0000313|Ensembl:ENSPPAP00000033642.1};
GN Name=APOL6 {ECO:0000313|Ensembl:ENSPPAP00000033642.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000033642.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000033642.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000033642.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the apolipoprotein L family.
CC {ECO:0000256|ARBA:ARBA00010090}.
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DR EMBL; AJFE02074057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003821562.1; XM_003821514.2.
DR AlphaFoldDB; A0A2R9BVD4; -.
DR STRING; 9597.ENSPPAP00000033642; -.
DR Ensembl; ENSPPAT00000056518.1; ENSPPAP00000033642.1; ENSPPAG00000039686.1.
DR GeneID; 100980449; -.
DR KEGG; pps:100980449; -.
DR CTD; 80830; -.
DR GeneTree; ENSGT01030000234599; -.
DR OMA; KLRADPH; -.
DR OrthoDB; 5265945at2759; -.
DR Proteomes; UP000240080; Chromosome 22.
DR Bgee; ENSPPAG00000039686; Expressed in liver and 5 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:InterPro.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR InterPro; IPR008405; ApoL.
DR PANTHER; PTHR14096; APOLIPOPROTEIN L; 1.
DR PANTHER; PTHR14096:SF7; APOLIPOPROTEIN L6; 1.
DR Pfam; PF05461; ApoL; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 79..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 268..295
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 343 AA; 38085 MW; 429D8A99C0C2D60F CRC64;
MDNQAERESE AGVGLQRDED DAPLCEDVEL QDGDLSPEEK IFLREFPRLK EDLKGNIDKL
RALADDIDKT HKKFTKANMV ATSTAVVSGV MSLLGLALAP ATGGGSLLLS TAGQGLATAA
GVTSIVSGTL ERSKNKEAQA RAEDILPTYD QEDREDEEEK ADYVTATGKI ICDLRNTLKY
AKKNIRAFWK LRANPRLAKA TKRLLTTGQV SSRSRVQVQK AFAGTTLAMT KNARVLGGVM
SAFSLGYDLA TLSKEWKHLK EGAKTKFAEE LRAKALELER KLTELTQLYK SLQQKVRSRA
RGVGKDLTGT CETEAYWKEL REHVWMWLWL CVCLCVCVYV QFT
//
