ID A0A2R9BWH0_PANPA Unreviewed; 1194 AA.
AC A0A2R9BWH0;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Insulin receptor substrate 4 {ECO:0000313|Ensembl:ENSPPAP00000034033.1};
GN Name=IRS4 {ECO:0000313|Ensembl:ENSPPAP00000034033.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000034033.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000034033.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000034033.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJFE02067321; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02067322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9BWH0; -.
DR STRING; 9597.ENSPPAP00000034033; -.
DR Ensembl; ENSPPAT00000056914.1; ENSPPAP00000034033.1; ENSPPAG00000039881.1.
DR GeneTree; ENSGT00940000160883; -.
DR OMA; VIFNPAM; -.
DR Proteomes; UP000240080; Chromosome X.
DR GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR CDD; cd01257; PH_IRS; 1.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF2; INSULIN RECEPTOR SUBSTRATE 4; 1.
DR Pfam; PF02174; IRS; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 168..272
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 343..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1116..1194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..579
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..638
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..762
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..855
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1157..1194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1194 AA; 126892 MW; 34BB80F2CC82C3A5 CRC64;
MASCSFTRDQ ATRRLRGAAA AAAAALAAVV TTPLLSSGTP TALIGTGSSC PGAMWLSTAT
GSRSDSESEE EDLPVGEEVC KRGYLRKQKH GHRRYFVLKL ETADAPARLE YYENARKFRH
SVRAAAAAAA AAASGAAIPP LIPPRRVITL YQCFSVSQRA DARYRHLIAL FTQDEYFAMV
AENEKELSGV FRLCLTDEEV VFVRLNTEVA SVVVQLLSIR RCGHSEQYFF LEVGRSTVIG
PGELWMQVDD CVVAQNMHEL FLEKMRALCA DEYRARCRSY SISIGAHLLT LLSARRHLGL
VPLEPGGWLR RSRFEQFCHL RAIGDGEDEM LFTRRFVTPS EPVAHSRRGR LHLPRGRRSR
RAVSVPASFF RRLAPSPARP RHPAEAPNNG ARLSSEVSRS GSGNSGEEGN PQGKEDQEGS
GGDYMPMNNW GSGNGRGSGG GQGSNGQGSS SHSSGGNQCS GEGQGSRGGQ GSNGQGSGGN
QCSRDGQGTA GGHGSGGGQR PGGGHGSGGG QGPGDGHGSG GGKNSGGGKG SGSGKGSDGD
GERGKSLKKR SYFGKLTQSK QQQMPPPPPP PPPPPPAGAT GGKGKSGGRF RLYFCADRGA
TKERKEAKEV KDAEIPEGAA RGPHRARAFD EDEDDPYVPM RPGVATPLVS SSDYMPMAPQ
NVSASKKRHS RSPFEDSRGY MMMFPRVSPP PAPSPPKAPD TNKEDNSKDN DSESDYMFMA
PGAGAIPKNP RNPQGGSSSK SWSSYFSLPN PFRSSPLGQN DNSEYVPMLP GKFLGRGLDK
EVSYNWDPKD AASKPSGEGS FSKPGDGGSP SKPSDDEPPK NKAKRPNRLS FITKGYKIKP
KPQKPTHEQR EADSSSDYVN MDFTKRESNT PAPSTQGLPD SWGIIAEPRQ SAFSNYVNVE
FGVPFPNPAN DLSDLLRAIP RANPLSLDSA RWPLPPLPLS ATGSNAIEEE GDYIEVIFNS
AMTPAMALAD SAIRYDAETG RIYVVDPFSE CCMDISLSPS RCSEPPPVAR LLQEEEQERR
RPQSRSQSFF AAARAAVSAF PTDSLERDLS PSSAPAVASA AEPTLALSQV VAAASALAAA
PGIGAAAAAA GFDSASARWF QPVANAADAE AVRGAQDVAG GSNPGAHNPS ANLARGDNQA
GGAAAAAAAP EPPPRSRRVP RPPEREDSDN DDDTYVRMDF ARRDNQFDSP KRGR
//
