ID A0A2R9BXR9_PANPA Unreviewed; 764 AA.
AC A0A2R9BXR9;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Sodium channel epithelial 1 subunit delta {ECO:0000313|Ensembl:ENSPPAP00000034261.1};
GN Name=SCNN1D {ECO:0000313|Ensembl:ENSPPAP00000034261.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000034261.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000034261.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000034261.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AJFE02029232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02029233; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9BXR9; -.
DR STRING; 9597.ENSPPAP00000034261; -.
DR Ensembl; ENSPPAT00000057142.1; ENSPPAP00000034261.1; ENSPPAG00000039962.1.
DR GeneTree; ENSGT00940000162685; -.
DR Proteomes; UP000240080; Chromosome 1.
DR Bgee; ENSPPAG00000039962; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034706; C:sodium channel complex; IEA:Ensembl.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR GO; GO:0071468; P:cellular response to acidic pH; IEA:Ensembl.
DR GO; GO:0006883; P:intracellular sodium ion homeostasis; IEA:Ensembl.
DR GO; GO:0098719; P:sodium ion import across plasma membrane; IEA:Ensembl.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR InterPro; IPR020903; ENaC_CS.
DR NCBIfam; TIGR00859; ENaC; 1.
DR PANTHER; PTHR11690:SF132; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT DELTA; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022461}.
FT REGION 139..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..170
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 764 AA; 83842 MW; 0E586B65782CD0E0 CRC64;
MRAVLSQKTT PLPCYLWPGH LSGPRRLTWS WCSDHRTPTC RELGSPHPTP CTWPARGWPR
RGGGPCGFTS AGHVLCGHPL CLLSGLIQGC GTGLGDSSMA SLSRTSPVAA ASFQSRQSPW
PVAPQRPCHL KGWQHRPTQH NAACKQGQAA AQTPPRPGPP SAPPPPPKEG HQEGLVELPA
SFRELLTFFC TNATIHGAIR LVCSRGNRLK TTSWGLLSLG ALVALCWQLG LLFERHWHRP
VLMAVSVHSE RKLLPLVTLC DGNPRRPSPV LRHLELLDEF ARENIDSLYN VNLSQGRAAL
SAPVPRHEPP FHLDREIRLQ RLSHSGSRVR VGFRLCNSTG GDCFYRGYTS GVAAVQDWYH
FHYVDILALL PAAWEDSHGS QDGHFVLSCS YDGLDCQARQ FRTFHHPTYG SCYTVDGVWT
AQRPGITHGV GLVLRVEQQP HLPLLSTLAG IRVMVHGRNH TPFLGHHSFS VRPGTEATIS
IREDEVHRLG SPYGHCTAGP EGVEVELLHN TSYTRQACLV SCFQQLMVET CSCGYYLHPL
PAGAEYCSSA RHPAWGHCFY RLYQDLETHR LPCTSRCPRP CRESAFKLST GTSRWPSAKS
AGWTLATLGE QGLPRQSHRQ RSSLAKINIV YQELNYRSVE EAPVYSVPQL LSAMGSLCSL
WFGASVLSLL ELLELLLDAS ALTLVLGGRR LRRAWFSWPR ASPASGASSI KPEASQMPTP
AGGTSDDPEP SGPHLPRVML PGVLAGVSAE ESWAGPQPLE TLDT
//
