ID A0A2R9BY13_PANPA Unreviewed; 2017 AA.
AC A0A2R9BY13;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Dedicator of cytokinesis 3 {ECO:0000313|Ensembl:ENSPPAP00000033370.1};
GN Name=DOCK3 {ECO:0000313|Ensembl:ENSPPAP00000033370.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000033370.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000033370.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000033370.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; AJFE02064246; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02064247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02064248; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02064249; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02064250; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02064251; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02064252; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02064253; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02064254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02064255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9597.ENSPPAP00000033370; -.
DR Ensembl; ENSPPAT00000056245.1; ENSPPAP00000033370.1; ENSPPAG00000039464.1.
DR GeneTree; ENSGT00940000155514; -.
DR OMA; XQYETVV; -.
DR Proteomes; UP000240080; Chromosome 3.
DR Bgee; ENSPPAG00000039464; Expressed in cerebellum and 4 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08695; C2_Dock-B; 1.
DR CDD; cd11704; DHR2_DOCK3; 1.
DR CDD; cd12048; SH3_DOCK3_B; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037811; C2_Dock-B.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026800; DHR2_DOCK3.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR035767; DOCK3_SH3.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF4; DEDICATOR OF CYTOKINESIS PROTEIN 3; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..54
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 408..586
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1215..1622
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1721..1758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1836..1915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1938..2017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1721..1752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1858..1910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1951..1967
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1968..1992
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2017 AA; 231545 MW; 6F7A4B49A7730C64 CRC64;
ICSFRGSVPQ GLVLEIGETV QILEKCEGWY RGVSTKKPNV KGIFPANYIH LKKAIVSNRG
QYETVVPLED SIVTEVTATL QEWASLWKQL YVKHKVDLFY KLRHVMNELI DLRRQLLSGH
LTQDQVREVK RHITVRLDWG NEHLGLDLVP RKDFEVVDSD QISVSDLYKM HLSSRQSVQQ
STSQVDTMRP RHGETCRMPV PHHFFLSLKS FTYNTIGEDT DVFFSLYDMR EGKQISERFL
VRLNKNGGPR NPEKIERMCA LFTDLSSKDM KRDLYIVAHV IRIGRMLLND SKKGPPHLHY
RRPYGCAVLS ILDVLQSLTE VKEEKDFVLK VYTCNNESEW SQIHENIIRK SSAKYSAPSA
SHGLIISLQL LRGDMEQIRR ENPMIFNRGL AITRKLGFPD VIMPGDIRND LYLTLEKGDF
ERGGKSVQKN IEVTMYVLYA DGEILKDCIS LGSGEPNRSS YHSFVLYHSN SPRWGEIIKL
PIPIDRFRGS HLRFEFRHCS TKDKGEKKLF GFAFSPLMRD DGTTLSDDIH ELYVYKCDEN
STFNNHALYL GLPCCKEDYN GCPNIPSSLI FQRSTKESFF ISTQLSSTKL TQNVDLLALL
KWKAFPDRIM DVLGRLRHVS GEEIVKFLQD ILDTLFVILD DNTEKYGLLV FQSLVFIINL
LRDIKYFHFR PVMDTYIQKH FAGALAYKEL IRCLKWYMDC SAELIRQDHI QEAMRALEYL
FKFIVQSRIL YSRATCGMEE EQFRSSIQEL FQSIRFVLSL DSRNSETLLF TQAALLNSFP
TIFDELLQMF TVQEVAEFVR GTLGSMPSTV HIGQSMDVVK LQSIARTVDS RLFSFSESRR
ILLPVVLHHI HLHLRQQKEL LICSGILGSI FSIVKTSSLE ADVMEEVEMM VESLLDVLLQ
TLLTIMSKSH AQEAVRGQRC PQCTAEITGE YVSCLLSLLR QMCDTHFQHL LDNFQSKDEL
KEFLLKIFCV FRNLMKMSVF PRDWMVMRLL TSNIIVTTVQ YLSSALHKNF TETDFDFKVW
NSYFSLAVLF INQPSLQLEI ITSAKRKKIL DKYGDMRVMM AYELFSMWQN LGEHKIHFIP
GMIGPFLGVT LVPQPEVRNI MIPIFHDMMD WEQRKNGNFK QVEAELIDKL DSMVSEGKGD
ESYRELFSLL TQLFGPYPSL LEKVEQETWR ETGISFVTSV TRLMERLLDY RDCMKGEETE
NKKIGCTVNL MNFYKSEINK EEMYIRYIHK LCDMHLQAEN YTEAAFTLLL YCELLQWEDR
PLREFLHYPS QTEWQRKEGL CRKIIHYFNK GKSWEFGIPL CRELACQYES LYDYQSLSWI
RKMEASYYDN IMEQQRLEPE FFRVGFYGRK FPFFLRNKEY VCRGHDYERL EAFQQRMLSE
FPQAVAMQHP NHPDDAILQC DAQYLQIYAV TPIPDYVDVL QMDRVPDRVK SFYRVNNVRK
FRYDRPFHKG PKDKENEFKS LWIERTTLTL THSLPGISRW FEVERRELVE VSPLENAIQV
VENKNQELRS LISQYQHKQV HGNINLLSMC LNGVIDAAVN GGIARYQEAF FDKDYINKHP
GDAEKITQLK ELMQEQVHVL GVGLAVHEKF VHPEMRPLHK KLIDQFQMMR ASLYHEFPGL
DKLSPACSGT NTPRGNVLAS HSPMSPESIK MTHRHSPMNL MGTGRHSSSS LSSHASSEAG
NMVMLGDGSM GDAPEDLYHH MQLAYPNPRY QGSVTNVSVL SSSQASPSSS SLSSTHSAPS
QMITSAPSSA RGSPSLPDKY RHAREMMLLL PTYRDRPSSA MYPAAILENG QPPNFQRALF
QQVVGACKPC SDPNLSVAEK GHYSLHFDAF HHPLGDTPPA LPARTLRKSP LHPIPASPTS
PQSGLDGSNS TLSGSASSGV SSLSESNFGH SSEAPPRTDT MDSTPSQAWN ADEDLEPPYL
PVHYSLSESA VLDSIKAQPC RSHSAPGCVI PQDPMDPPAL PPKPYHPRLP ALEHDEGVLL
REETERPRGL HRKAPLPPGS AKEEQARMAW EHGRGEQ
//
