ID A0A2R9BYG6_PANPA Unreviewed; 553 AA.
AC A0A2R9BYG6;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Heterochromatin protein 1-binding protein 3 {ECO:0000256|ARBA:ARBA00019297};
GN Name=HP1BP3 {ECO:0000313|Ensembl:ENSPPAP00000034717.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000034717.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000034717.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000034717.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AJFE02046461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008965303.1; XM_008967055.1.
DR RefSeq; XP_008965304.1; XM_008967056.2.
DR AlphaFoldDB; A0A2R9BYG6; -.
DR SMR; A0A2R9BYG6; -.
DR STRING; 9597.ENSPPAP00000034717; -.
DR Ensembl; ENSPPAT00000057600.1; ENSPPAP00000034717.1; ENSPPAG00000040189.1.
DR GeneID; 100970538; -.
DR KEGG; pps:100970538; -.
DR CTD; 50809; -.
DR GeneTree; ENSGT00940000155314; -.
DR OMA; IQNCKER; -.
DR OrthoDB; 3029985at2759; -.
DR Proteomes; UP000240080; Chromosome 1.
DR Bgee; ENSPPAG00000040189; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0031491; F:nucleosome binding; IEA:Ensembl.
DR GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
DR GO; GO:0070828; P:heterochromatin organization; IEA:Ensembl.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0097298; P:regulation of nucleus size; IEA:Ensembl.
DR CDD; cd00073; H15; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 3.
DR InterPro; IPR005818; Histone_H1/H5_H15.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR15832:SF1; HETEROCHROMATIN PROTEIN 1-BINDING PROTEIN 3; 1.
DR PANTHER; PTHR15832; SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG; 1.
DR Pfam; PF00538; Linker_histone; 3.
DR SMART; SM00526; H15; 3.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS51504; H15; 3.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 157..232
FT /note="H15"
FT /evidence="ECO:0000259|PROSITE:PS51504"
FT DOMAIN 255..330
FT /note="H15"
FT /evidence="ECO:0000259|PROSITE:PS51504"
FT DOMAIN 337..413
FT /note="H15"
FT /evidence="ECO:0000259|PROSITE:PS51504"
FT REGION 29..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..79
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..447
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 61207 MW; D18B28EE0156F09B CRC64;
MATDTSQGEL VHPKALPLIV GAQLIHADKL GEKVEDSTMP IRRTVNSTRE TPPKSKLAEG
EEEKPEPDIS SEESVSTVEE QENETPPATS SEAEQPKGEP ENEEKEENKS SEETKKDEKD
QSKEKEKKVK KTIPSWATLS ASQLARAQKQ TPMASSPRPK MDAILTEAIK ACFQKSGASV
VAIRKYIIHK YPSLELERRG YLLKQALKRE LNRGVIKQVK GKGASGSFVV VQKSRKTPQK
SRNRKNRSSA VDPEPQVKLE DVLPLAFTRL CEPKEASYSL IRKYVSQYYP KLRVDIRPQL
LKNALQRAVE RGQLEQITGK GASGTFQLKK SGEKPLLGGS LMEYAILSAI AAMNEPKTCS
TTALKKYVLE NHPGTNSNYQ MHLLKKTLQK CEKNGWMEQI SGKGFSGTFQ LCFPYYPSPG
VLFPKKEPDD SRDEDEDEDE SSEEDSEDEE PPPKRRLQKK TPAKSPGKAA SVKQRGSKPA
PKVSAAQRGK ARPLPKKAPP KAKTPAKKTR PSSTVIKKPS GGSSKKPATS ARKEVKLPGK
GKSTMKKSFR VKK
//
