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Database: UniProt
Entry: A0A2R9BZK1_PANPA
LinkDB: A0A2R9BZK1_PANPA
Original site: A0A2R9BZK1_PANPA 
ID   A0A2R9BZK1_PANPA        Unreviewed;       789 AA.
AC   A0A2R9BZK1;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN   Name=STAT5B {ECO:0000313|Ensembl:ENSPPAP00000033925.1};
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000033925.1, ECO:0000313|Proteomes:UP000240080};
RN   [1] {ECO:0000313|Ensembl:ENSPPAP00000033925.1, ECO:0000313|Proteomes:UP000240080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22722832; DOI=10.1038/nature11128;
RA   Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA   Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA   Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA   Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA   Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA   Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA   Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA   Paabo S.;
RT   "The bonobo genome compared with the chimpanzee and human genomes.";
RL   Nature 486:527-531(2012).
RN   [2] {ECO:0000313|Ensembl:ENSPPAP00000033925.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU046415}.
CC   -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC       {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR   EMBL; AJFE02044483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02044484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02044485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2R9BZK1; -.
DR   STRING; 9597.ENSPPAP00000033925; -.
DR   Ensembl; ENSPPAT00000056806.1; ENSPPAP00000033925.1; ENSPPAG00000039557.1.
DR   GeneTree; ENSGT01080000257420; -.
DR   OMA; IWLNRQQ; -.
DR   Proteomes; UP000240080; Chromosome 17.
DR   Bgee; ENSPPAG00000039557; Expressed in cerebellum and 6 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0035259; F:nuclear glucocorticoid receptor binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0050798; P:activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0030183; P:B cell differentiation; IEA:Ensembl.
DR   GO; GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0046543; P:development of secondary female sexual characteristics; IEA:Ensembl.
DR   GO; GO:0046544; P:development of secondary male sexual characteristics; IEA:Ensembl.
DR   GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
DR   GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
DR   GO; GO:0042492; P:gamma-delta T cell differentiation; IEA:Ensembl.
DR   GO; GO:0060397; P:growth hormone receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR   GO; GO:0007595; P:lactation; IEA:Ensembl.
DR   GO; GO:0019915; P:lipid storage; IEA:Ensembl.
DR   GO; GO:0001553; P:luteinization; IEA:Ensembl.
DR   GO; GO:0097531; P:mast cell migration; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0033028; P:myeloid cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0001779; P:natural killer cell differentiation; IEA:Ensembl.
DR   GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR   GO; GO:0001787; P:natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0045647; P:negative regulation of erythrocyte differentiation; IEA:Ensembl.
DR   GO; GO:0033033; P:negative regulation of myeloid cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0048541; P:Peyer's patch development; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045579; P:positive regulation of B cell differentiation; IEA:Ensembl.
DR   GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
DR   GO; GO:0045588; P:positive regulation of gamma-delta T cell differentiation; IEA:Ensembl.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:0032743; P:positive regulation of interleukin-2 production; IEA:Ensembl.
DR   GO; GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
DR   GO; GO:0032825; P:positive regulation of natural killer cell differentiation; IEA:Ensembl.
DR   GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0042448; P:progesterone metabolic process; IEA:Ensembl.
DR   GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR   GO; GO:0030856; P:regulation of epithelial cell differentiation; IEA:Ensembl.
DR   GO; GO:0019218; P:regulation of steroid metabolic process; IEA:Ensembl.
DR   GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
DR   GO; GO:0070672; P:response to interleukin-15; IEA:Ensembl.
DR   GO; GO:0070669; P:response to interleukin-2; IEA:Ensembl.
DR   GO; GO:0070670; P:response to interleukin-4; IEA:Ensembl.
DR   GO; GO:0033077; P:T cell differentiation in thymus; IEA:Ensembl.
DR   GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
DR   GO; GO:0019530; P:taurine metabolic process; IEA:Ensembl.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR   CDD; cd10420; SH2_STAT5b; 1.
DR   CDD; cd16855; STAT5_CCD; 1.
DR   CDD; cd16849; STAT5_DBD; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR   Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR   Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR001217; STAT.
DR   InterPro; IPR046994; STAT5_CCD.
DR   InterPro; IPR035858; STAT5a/5b_DBD.
DR   InterPro; IPR035886; STAT5b_SH2.
DR   InterPro; IPR048988; STAT_linker.
DR   InterPro; IPR036535; STAT_N_sf.
DR   InterPro; IPR013800; STAT_TF_alpha.
DR   InterPro; IPR015988; STAT_TF_coiled-coil.
DR   InterPro; IPR013801; STAT_TF_DNA-bd.
DR   InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR   InterPro; IPR013799; STAT_TF_prot_interaction.
DR   PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR   PANTHER; PTHR11801:SF39; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF01017; STAT_alpha; 1.
DR   Pfam; PF02864; STAT_bind; 1.
DR   Pfam; PF02865; STAT_int; 1.
DR   Pfam; PF21354; STAT_linker; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00964; STAT_int; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF47655; STAT; 1.
DR   SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW   ECO:0000256|RuleBase:RU046415};
KW   Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU046415};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU046415}.
FT   DOMAIN          591..688
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
SQ   SEQUENCE   789 AA;  90276 MW;  3752219A3EE8F7E3 CRC64;
     MAVWIQAQQL QGEALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSIDLDN PQENIKATQL
     LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV
     REANNGSSPA GSLADAMSQK HLQINQTFEE LRLVTQDTEN ELKKLQQTQE YFIIQYQESL
     RIQGERFAQV HLQSRPQERL SRETALQQKQ VSLEAWLQRE AQTLQQYRVE LAEKHQKTLQ
     LLRKQQTIIL DDELIQWKRR QQLAGNGGPP EGSLDVLQSW CEKLAEIIWQ NRQQIRRAEH
     LCQQLPIPGP VEEMLAEVNA TITDIISALV TSTFIIEKQP PQVLKTQTKF AATVRLLVGG
     KLNVHMNPPQ VKATIISEQQ AKSLLKNENT RNDYSGEILN NCCVMEYHQA TGTLSAHFRN
     MSLKRIKRSD RRGAESVTEE KFTILFESQF SVGGNELVFQ VKTLSLPVVV IVHGSQDNNA
     TATVLWDNAF AEPGRVPFAV PDKVLWPQLC EALNMKFKAE VQSNRGLTKE NLVFLAQKLF
     NNSSSHLEDY SGLSVSWSQF NRENLPGRNY TFWQWFDGVM EVLKKHLKPH WNDGAILGFV
     NKQQAHDLLI NKPDGTFLLR FSDSEIGGIT IAWKFDSQER MFWNLMPFTT RDFSIRSLAD
     RLGDLNYLIY VFPDRPKDEV YSKYYTPVPC ESATAKAVDG YVKPQIKQVV PEFVNASADA
     GGGSATYMDQ APSPAVCPQA HYNMYPQNPD SVLDTDGDFD LEDTMDVARR VEELLGRPMD
     SQWIPHAQS
//
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