ID A0A2R9C0J2_PANPA Unreviewed; 447 AA.
AC A0A2R9C0J2;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=5-hydroxytryptamine receptor 3C {ECO:0000313|Ensembl:ENSPPAP00000032269.1};
GN Name=HTR3C {ECO:0000313|Ensembl:ENSPPAP00000032269.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000032269.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000032269.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000032269.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
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DR EMBL; AJFE02113447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003832043.1; XM_003831995.1.
DR AlphaFoldDB; A0A2R9C0J2; -.
DR STRING; 9597.ENSPPAP00000032269; -.
DR Ensembl; ENSPPAT00000055135.1; ENSPPAP00000032269.1; ENSPPAG00000039021.1.
DR GeneID; 100982404; -.
DR KEGG; pps:100982404; -.
DR GeneTree; ENSGT00940000156739; -.
DR OMA; CVGINKL; -.
DR OrthoDB; 5489962at2759; -.
DR Proteomes; UP000240080; Chromosome 3.
DR GO; GO:1904602; C:serotonin-activated cation-selective channel complex; IEA:Ensembl.
DR GO; GO:0022850; F:serotonin-gated monoatomic cation channel activity; IEA:Ensembl.
DR GO; GO:0098662; P:inorganic cation transmembrane transport; IEA:Ensembl.
DR CDD; cd19013; LGIC_ECD_5-HT3C_E; 1.
DR CDD; cd19063; LGIC_TM_5-HT3; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945:SF931; 5-HYDROXYTRYPTAMINE RECEPTOR 3C; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Signal {ECO:0000256|RuleBase:RU000687};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687}; Transport {ECO:0000256|RuleBase:RU000687}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT CHAIN 28..447
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT /id="PRO_5022266129"
FT TRANSMEM 249..271
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 283..302
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 308..333
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 52..247
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 254..362
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT REGION 380..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 50175 MW; C5A1879007E2CA0B CRC64;
MEGGWPARQS ALLCLTVSLL LQGRGDAFTI NCSGFDQHGV DPAVFQAVFD RKAFRPFTNY
SIPTRVNISF TLSAILGVDA QLQLLTSFLW MDLVWDNPFI NWNPKECVGI NKLTVLAENL
WLPDIFIMES MDVDQTPSGL TAYISSEGRI KYDKPMRVTS ICNLDIFYFP FDQQNCTFTF
SSFLYTVDSM LLGMDKEVWE ITDTSRKVIQ TQGEWELLGI NKATPKMSVG NNLYDQIMFY
VAIRRRPSLY IINLLVPSSF LVAIDALSFY LPAESENRAP FKITLLLGYN VFLLMMNDLL
PASGTPLISV YFALCLSLMV VSLLETVFIT HLLHVATTQP PPMPRWLHSL LLHRTSPGRC
CPTAPQKGNK GLGLTLTHLP GPKEPGELAG KKLGPRETEP DGGSGWTKTQ LMGLWVQFSH
AMDTLLFRLY LLFMASSILT VIVLWNT
//
