ID A0A2R9C0J5_PANPA Unreviewed; 549 AA.
AC A0A2R9C0J5;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Embryonal Fyn-associated substrate {ECO:0000313|Ensembl:ENSPPAP00000032274.1};
GN Name=EFS {ECO:0000313|Ensembl:ENSPPAP00000032274.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000032274.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000032274.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000032274.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CAS family. {ECO:0000256|ARBA:ARBA00007848}.
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DR EMBL; AJFE02024194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9C0J5; -.
DR STRING; 9597.ENSPPAP00000032274; -.
DR Ensembl; ENSPPAT00000055140.1; ENSPPAP00000032274.1; ENSPPAG00000039022.1.
DR GeneTree; ENSGT00950000183008; -.
DR OMA; LHNEYEG; -.
DR Proteomes; UP000240080; Chromosome 14.
DR Bgee; ENSPPAG00000039022; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd11571; FAT-like_EFS_C; 1.
DR CDD; cd12003; SH3_EFS; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR021901; CAS_C.
DR InterPro; IPR037362; CAS_fam.
DR InterPro; IPR035747; EFS_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10654; CAS SCAFFOLDING PROTEIN; 1.
DR PANTHER; PTHR10654:SF14; EMBRYONAL FYN-ASSOCIATED SUBSTRATE; 1.
DR Pfam; PF12026; CAS_C; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 5..67
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 67..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..87
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..122
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..197
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..313
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..335
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..360
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 57519 MW; FE271C54941F3698 CRC64;
MAIATSAQLA RALYDNTAES PQELSFRRGD VLRVLQREGA GLDGWCLCSL HGQQGIVPAN
RVKLLPAGPA PKPSLSPASP AQPGSPYPAP DHSNEDQEVY VVPPPARPCP TSGPPAGPCP
PSPDLIYKIP RASGTQLAAP RDALEVYDVP PTALRVPSSG PYDCPASFSH PLTRVAPQPP
GEDDAPYDVP LTPKPPAELE PDLQWEGGRE PGPPIYAAPS NLKRASALLN LYEAPEELLA
DGEGGGTDEG IYDVPLLGPE APPSPEPPGA LASHDQDTLA QPRLPSAESL SRRPLPALPV
PEAPSPSPVP SPAPGRKGSI QDRPLPPPPP RLPGYGGPKV EGDPEGREME DDPAGHHNEY
EGIPMAEEYD YVHLKGMDKA QGSRPPDQAC TGDPELPERG MPAPQEALSP GEPLVLSTGD
LQLLYFYAGQ CQSHYSALQA AVAALMSSTQ ANQPPRLFVP HSKRVVVAAH RLVFVGDTLG
RLAASAPLRA QVRAAGTALG QALRATVLAV KGAALGYPSS PAIQEMVQCV TELAGQALQF
TTLLTSLAP
//
