ID A0A2R9C130_PANPA Unreviewed; 651 AA.
AC A0A2R9C130;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Kinesin-like protein {ECO:0000256|RuleBase:RU000394};
GN Name=KIF12 {ECO:0000313|Ensembl:ENSPPAP00000034470.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000034470.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000034470.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000034470.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283,
CC ECO:0000256|RuleBase:RU000394}.
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DR EMBL; AJFE02119114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003833121.1; XM_003833073.2.
DR AlphaFoldDB; A0A2R9C130; -.
DR STRING; 9597.ENSPPAP00000034470; -.
DR Ensembl; ENSPPAT00000057353.1; ENSPPAP00000034470.1; ENSPPAG00000040072.1.
DR GeneID; 100973764; -.
DR KEGG; pps:100973764; -.
DR CTD; 113220; -.
DR GeneTree; ENSGT00940000161216; -.
DR OMA; YISHQTA; -.
DR OrthoDB; 316647at2759; -.
DR Proteomes; UP000240080; Chromosome 9.
DR Bgee; ENSPPAG00000040072; Expressed in adult mammalian kidney and 5 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00106; KISc; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47969; CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED; 1.
DR PANTHER; PTHR47969:SF15; ZGC:66125; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|RuleBase:RU000394};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 25..365
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 584..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 387..468
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 542..557
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 109..116
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 651 AA; 71115 MW; B531231D4B9122FC CRC64;
MEERGSPDGD LARSLEQGPE GPETPIQVVL RVRPMSAAEL RRGQQSVLHC SGTRTLQVSP
LGGGPEVAFR FGAVLDAART QEDVFRACGV RRLGELALRG FSCTVFTFGQ TGSGKTYTLT
GPPPQGEGVP VPPSLAGIMQ RTFAWLLDRV QHLGAPVTLR ASYLEIYNEQ VRDLLSLGSP
RPLPVRWNKT RGFYVEQLRV VEFGSLEALM ELLQTGLSRR RSSAHTLNQA SSRSHALLTL
YISRQTAQQM PSVDPGEPPV GGKLCFVDLA GSEKVAATGS RGELMLEANS INRSLLALGH
CISLLLDPQR KQSHIPFRDS KLTKLLADSL GGRGVTLMVA CVSPSAQCLP ETLSTLRYAS
RAQRVTTRPQ APKSPVAKQP QRLETEMLQL QEENRRLQFQ LDQMDCKASG LSGARVAWAQ
RNLYGMLQEF MLENERLRKE KSQLQNSRDL ARNEQRILAQ QVHALERRLL SACYHHQQGP
GLTPPCPCLM APAPPCHALP PLYSCPCCHI CPLCRVPLAH WACLPGEHHL PQVLDPEASG
GRPPSARPPP WAPPCSPGSA KCPRERSHSD WTQTRVLAEM LTEEEVVPSA PPLPVRPPKT
SPGLRGGAGV PNLAQRLEAL RDQIGSSLRR GRSQPPCSEG ARSPGQVLPP H
//
