ID A0A2R9C1L6_PANPA Unreviewed; 1325 AA.
AC A0A2R9C1L6;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=SOS Ras/Rho guanine nucleotide exchange factor 2 {ECO:0000313|Ensembl:ENSPPAP00000035804.1};
GN Name=SOS2 {ECO:0000313|Ensembl:ENSPPAP00000035804.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000035804.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000035804.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000035804.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AJFE02112189; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02112190; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02112191; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02112192; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02112193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02112194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02112195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9597.ENSPPAP00000035804; -.
DR Ensembl; ENSPPAT00000058693.1; ENSPPAP00000035804.1; ENSPPAG00000040633.1.
DR GeneTree; ENSGT00940000158324; -.
DR OMA; KNTHRED; -.
DR Proteomes; UP000240080; Chromosome 14.
DR Bgee; ENSPPAG00000040633; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0001782; P:B cell homeostasis; IEA:Ensembl.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:2000973; P:regulation of pro-B cell differentiation; IEA:Ensembl.
DR GO; GO:0033081; P:regulation of T cell differentiation in thymus; IEA:Ensembl.
DR GO; GO:0042129; P:regulation of T cell proliferation; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:Ensembl.
DR CDD; cd01261; PH_SOS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF150; SON OF SEVENLESS HOMOLOG 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1325
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015319144"
FT DOMAIN 190..380
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 433..536
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 587..731
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 770..1010
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1011..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1069..1089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1135..1325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1027..1047
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1144..1158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1182
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1190..1218
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1279..1294
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1325 AA; 152321 MW; 8D16E1CAC156D1CF CRC64;
YNAQFYAIFF FLRWSCPGWS AVQEQVHPTL SANEESLYYI EELIFQLLNK LCMAQPRTVQ
DVEERVQKTF PHPIDKWAIA DAQSAIEKRK RRNPLLLPVD KIHPSLKEVL GYKVDYHVSL
YIVAVLEYIS ADILKLAGNY VFNIRHYEIS QQDIKVSMCA DKVLMDMFDQ DDIGLVSLCE
DEPSSSGELN YYDLVRTEIA EERQYLRELN MIIKVFREAF LSDRKLFKPS DIEKIFSNIS
DIHELTVKLL GLIEDTVEMT DESSPHPLAG SCFEDLAEEQ AFDPYETLSQ DILSPEFHEH
FNKLMARPAV ALHFQSIADG FKEAVRYVLP RLMLVPVYHC WHYFELLKQL KACSEEQEDR
ECLNQAITAL MNLQGSMDRI YKQYSPRRRP GDPVCPFYSH QLRSKHLAIK KMNEIQKNID
GWEGKDIGQC CNEFIMEGPL TRIGAKHERH IFLFDGLMIS CKPNHGQTRL PGYSSAEYRL
KEKFVMRKIQ ICDKEDTCEY KHAFELVSKD ENSIIFAAKS AEEKNNWMAA LISLHYRSTL
DRMLDSVLLK EENEQPLRLP SPEVYRFVVK DSEENIVFED NLQSRSGIPI IKGGTVVKLI
ERLTYHMYAD PNFVRTFLTT YRSFCKPQEL LSLLIERFEI PEPEPTDADK LAIEKGEQPI
SADLKRFRKE YVQPVQLRIL NVFRHWVEHH FYDFERDLEL LERLESFISS VRGKAMKKWV
ESIAKIIRRK KQAQANGISH NITFESPPPP IEWHISKPGQ FETFDLMTLH PIEIARQLTL
LESDLYRKVQ PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV EAENFEERVA
VLSRIIEILQ VFQDLNNFNG VLEIVSAVNS VSVYRLDHTF EALQERKRKI LDEAVELSQD
HFKKYLVKLK SINPPCVPFL VRIYLTNILK TEEGNNDFLK KKGKDLINFS KRRKVAEITG
EIQQYQNQPY CLRIEPDMRR FFENLNPMGS ASEKEFTDYL FNKSLEIEPR NCKQPPRFPR
KSTFSLKSPG IRPNTGRHGS TSGTLRGHPT PLEREPCKIS FSRIAETELE STVSAPTSPN
TPSTPPVSAS SDLSVFLDVD LNSSCGSNSI FAPVLLPHSK SFFSSCGSLH KLSEEPLIPP
PLPPRKKFDH DASNSKGNMK SDDDPPAIPP RQPPPPKVKP RVPVPTGAFD GPLHSPPPPP
PRDPLPDTPP PVPLRPPEHF INCPFNLQPP PLGHLHRDSD WLRDISTCPN SPSTPPSTPS
PRVPRRCYVL SSSQNNLAHP PAPPVPPRQN SSPHLPKLPP KTYKRELSHP PLYRLPLLEN
AETPQ
//
