ID A0A2R9C2E1_PANPA Unreviewed; 1219 AA.
AC A0A2R9C2E1;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Intersectin 1 {ECO:0000313|Ensembl:ENSPPAP00000035907.1};
GN Name=ITSN1 {ECO:0000313|Ensembl:ENSPPAP00000035907.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000035907.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000035907.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000035907.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AJFE02084457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02084458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02084459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02084460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02084461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02084462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02084463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02084464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9C2E1; -.
DR Ensembl; ENSPPAT00000058796.1; ENSPPAP00000035907.1; ENSPPAG00000040351.1.
DR GeneTree; ENSGT00940000157065; -.
DR OMA; XCSDLHL; -.
DR Proteomes; UP000240080; Chromosome 21.
DR Bgee; ENSPPAG00000040351; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00052; EH; 2.
DR CDD; cd11991; SH3_Intersectin1_3; 1.
DR CDD; cd11995; SH3_Intersectin1_5; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 5.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR032140; INTAP.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR11216; EH DOMAIN; 1.
DR PANTHER; PTHR11216:SF68; INTERSECTIN-1; 1.
DR Pfam; PF12763; EF-hand_4; 2.
DR Pfam; PF16617; INTAP; 1.
DR Pfam; PF00018; SH3_1; 3.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00027; EH; 2.
DR SMART; SM00326; SH3; 5.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF50044; SH3-domain; 5.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50031; EH; 2.
DR PROSITE; PS50002; SH3; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 21..99
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 52..87
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 220..309
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 253..288
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 739..805
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 912..970
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1001..1059
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1073..1137
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1154..1213
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 321..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 354..508
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 329..347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..867
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1219 AA; 137502 MW; 9A2072DBD2ACD483 CRC64;
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFQS GLPQPVLAQI
WALADMNNDG RMDQVEFSIA MKLIKLKLQG YQLPSALPPV MKQQPVAISS APAFGMGGIA
SMPPLTAVAP VPMGSIPVVG MSPTLVSSVP TAAVPPLANG APPVIQPLPA FAHPAATLPK
SSSFSRSGPG SQLNTKLQKA QSFDVASVPP VAEWAVPQSS RLKYRQLFNS HDKTMSGHLT
GPQARTILMQ SSLPQAQLAS IWNLSDIDQD GKLTAEEFIL AMHLIDVAMS GQPLPPVLPP
EYIPPSFRRV RSGSGISVIS STSVDQRLPE EPVLEDEQQQ LEKKLPVTFE DKKRENFERG
NLELEKRRQA LLEQQRKEQE RLAQLERAEQ ERKERERQEQ ERKRQLELEK QLEKQRELER
QREEERRKEI ERREAAKREL ERQRQLEWER NRRQELLNQR NKEQEDIVVL KAKKKTLEFE
LEALNDKKHQ LEGKLQDIRC RLTTQRQEIE STNKSRELRI AEITHLQQQL QESQQMLGRL
IPEKQILNDQ LKQVQQNSLH RDSLVTLKRA LEAKELARQQ LRDQLDEVEK ETRSKLQEID
IFNNQLKELR EIHNKQQLQK QKSMEAERLK QKEQERKIIE LEKQKEEAQR RAQERDKQWL
EHVQQEDEHQ RPRKLHEEEK LKREESVKKK DGEEKGKQEA QDKLGRLFHQ HQEPAKPAVQ
APWPTAEKGP LTISAQENVK VVYYRALYPF ESRSHDEITI QPGDIVMVKG EWVDESQTGE
PGWLGGELKG KTGWFPANYA EKIPENEVPA PVKPVTDSTS APAPKLALRE TPAPLAVTSS
EPSTTPNNWA DFSSTWPTST NEKPETDNWD AWAAQPSLTV PSAGQLRQRS AFTPATATGS
SPSPVLGQGE KVEGLQAQAL YPWRAKKDNH LNFNKNDVIT VLEQQDMWWF GEVQGQKGWF
PKSYVKLISG PIRKSTSMDS GSSESPASLK RVASPAAKPV VSGEEFIAMY TYESSEQGDL
TFQQGDVILV TKKDGDWWTG TVGDKAGVFP SNYVRLKDSE GSGTAGKTGS LGKKPEIAQV
IASYTATGPE QLTLAPGQLI LIRKKNPGGW WEGELQARGK KRQIGWFPAN YVKLLSPGTS
KITPTEPPKS TALAAVCQVI GMYDYTAQND DELAFNKGQI INVLNKEDPD WWKGEVNGQV
GLFPSNYVKL TTDMDPSQQ
//
