ID A0A2R9C3C7_PANPA Unreviewed; 803 AA.
AC A0A2R9C3C7;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Exportin-T {ECO:0000256|ARBA:ARBA00018928, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=Exportin(tRNA) {ECO:0000256|ARBA:ARBA00029784, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=tRNA exportin {ECO:0000256|ARBA:ARBA00032199, ECO:0000256|RuleBase:RU366037};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000036461.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000036461.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000036461.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex.
CC {ECO:0000256|RuleBase:RU366037}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU366037}.
CC Cytoplasm {ECO:0000256|RuleBase:RU366037}. Note=Shuttles between the
CC nucleus and the cytoplasm. {ECO:0000256|RuleBase:RU366037}.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|RuleBase:RU366037}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJFE02021791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9C3C7; -.
DR STRING; 9597.ENSPPAP00000036461; -.
DR Ensembl; ENSPPAT00000059353.1; ENSPPAP00000036461.1; ENSPPAG00000040981.1.
DR GeneTree; ENSGT00390000007890; -.
DR OMA; RMIICPE; -.
DR Proteomes; UP000240080; Chromosome 7.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952:SF12; EXPORTIN-T; 1.
DR PANTHER; PTHR15952; EXPORTIN-T/LOS1; 1.
DR Pfam; PF19282; Exportin-T; 3.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU366037};
KW Nucleus {ECO:0000256|RuleBase:RU366037};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU366037};
KW Transport {ECO:0000256|RuleBase:RU366037};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555,
KW ECO:0000256|RuleBase:RU366037}.
FT DOMAIN 126..170
FT /note="Exportin-1/Importin-beta-like"
FT /evidence="ECO:0000259|Pfam:PF08389"
FT DOMAIN 241..551
FT /note="Exportin-T C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19282"
FT DOMAIN 568..650
FT /note="Exportin-T C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19282"
FT DOMAIN 665..800
FT /note="Exportin-T C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19282"
SQ SEQUENCE 803 AA; 91974 MW; 4979DA85A9A182A6 CRC64;
MDEQAVLGPK SNADSDFRQR ALAYFERLKI SPDAWQVFKY KYSELTTVQQ QLIRETLISW
LQAQMLNPQP EKTFIRNKAA QVFALLFVTE YLTKWPKCVP ANPHGYRFRV VHSKSGGMVV
PNITKLSCFE VVGAYVSWID LPLIANDRFI SVLLGHMSIE VLREEACDCL FEVVNKGMDP
VDKMKLVESL CQVLQSAGSF SIDQEEDVDF LAGFSKLVNG KGQSLIDSWS KLIKNGDIKN
AQEALQAIET KVALMLQLLI HENDDISPNI IGFCYYYLHI WKQLTVLSDQ QKANVEAIML
AVMKKLTYDE EYNFENEGED EAMFVEYRKQ LKLLLDRLAQ VSPELLVASV HSVFSSTLQD
WQTTWFMEVE VAIRLLDMAG REALLVSHGV PFAGDVSKAS ALQDMRILVT SRVSSYQHTS
VTLEFFKNVV RYEKFFTVEP QHIPRVLMAF LDHRSLRHSS AKVWSRMTYL FSRFVKSLNK
QMNPLTEDIL NRIQDLLELS PPENGHQSLL GSDDQLFIYE TAGVLTVNSE YLAERKQALV
RNLLTPLMEK FKILHSCQPS VVPYKRIILR SGVRTFLHRM VICLGEEVFP FIPTASERML
KDCEAEDLRE FILLINQITA KFKRQVSPFL QQMFMPLLHA IFEVLLRPAE ENDYYSKSGC
TKCRVLVTVT QGAVEYPDPI AQKTCFIILS KLVELWRGKD GPVGFADFVY KHIVPSCFLA
PLKQTFDLAD AQTVLALSEC AVTLKTIHLK WGPECVQYLQ QEYLPSLQVG PEIIQEFCQA
LQQPDAKVFK NYLKVFFQRA KPY
//
