ID A0A2R9C5Y4_PANPA Unreviewed; 460 AA.
AC A0A2R9C5Y4;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta {ECO:0000313|Ensembl:ENSPPAP00000036308.1};
GN Name=HADHB {ECO:0000313|Ensembl:ENSPPAP00000036308.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000036308.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000036308.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; AJFE02095092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02095093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02095094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02095095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9C5Y4; -.
DR Ensembl; ENSPPAT00000059200.1; ENSPPAP00000036308.1; ENSPPAG00000040869.1.
DR GeneTree; ENSGT01030000234626; -.
DR Proteomes; UP000240080; Unplaced.
DR Bgee; ENSPPAG00000040869; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003988; F:acetyl-CoA C-acyltransferase activity; IEA:UniProt.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR18919:SF147; TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Transferase {ECO:0000256|RuleBase:RU003557};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 40..310
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 317..456
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
SQ SEQUENCE 460 AA; 49816 MW; 29D9FCA070A09541 CRC64;
MTTILTYPFK NLPTASKWAL RFSVQTKTKK TLAKPNIRNV VVVDGVRTPF LLSGTSYKDL
MPHDLARAAL TGLLHRTSVP KEVVDYIIFG TVIQEVKTSN VAREAALGAG FSDKTPAHTV
TMACISANQA MTTGVGLIAS GQCDVIVAGG VELMSDVPIR HSRKMRKLML DLNKAKSMGQ
RLSLISKFRF NFLAPELPAV SEFSTSETMG HSADRLAAAF AVSRLEQDEY ALRSHSLAKK
AQDEGLLSDV VPFKVPGKDT VTKDNGIRPS SLEQMAKLKP AFIKPYGTVT AANSSFLTDG
ASAMLIMAEE KALAMGYKPK AYLRDFMYVS QDPKDQLLLG PTYATPKVLE KAGLTMNDID
AFEFHEAFSG QILANFKAMD SDWFAENYMG RKTKVGLPPL EKFNNWGGSL SLGHPFGATG
CRLVMAAANR LQKEGGQYGL VAACAAGGQG HAMIVEAYPK
//
