ID A0A2R9C695_PANPA Unreviewed; 958 AA.
AC A0A2R9C695;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Diaphanous related formin 2 {ECO:0000313|Ensembl:ENSPPAP00000036418.1};
GN Name=DIAPH2 {ECO:0000313|Ensembl:ENSPPAP00000036418.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000036418.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000036418.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000036418.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
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DR EMBL; AJFE02032154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02032155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02032156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02032157; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02032158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02032159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02032160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02032161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02032162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02032163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9C695; -.
DR Ensembl; ENSPPAT00000059310.1; ENSPPAP00000036418.1; ENSPPAG00000040909.1.
DR GeneTree; ENSGT00940000157822; -.
DR Proteomes; UP000240080; Chromosome X.
DR Bgee; ENSPPAG00000040909; Expressed in placenta and 5 other cell types or tissues.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 6.10.30.30; -; 1.
DR Gene3D; 1.10.20.40; Formin, diaphanous GTPase-binding domain; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR044933; DIA_GBD_sf.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF3; PROTEIN DIAPHANOUS HOMOLOG 2; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 87..460
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 624..958
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 199..226
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 377..404
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 29..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..590
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 958 AA; 108401 MW; 3A7EDB2929A14204 CRC64;
MEQPGAAASG AGGGSEEPGG GRSNKRSAGN RAANEEETKN KPKLRDRITS FRKSTVKKEK
PLIQHPIDSQ VAMSEFPAAQ PLYDERSLNL SEKEVLDLFE KMMEDMNLNE EKKAPLRNKD
FTTKREMVVQ YISATAKSIV GSKVTGGLKN SKHECTLSSQ EYVHELRSGI SDEKLLNCLE
SLRVSLTSNP VSWVNNFGHE GLGLLLDELE KLLDKKQQEN IDKKNQYKLI QCLKAFMNNK
FGLQRILGDE RSLLLLARAI DPKQPNMMTE IVKILSAICI VGEENILDKL LGAITTAAER
NNRERFSPIV EGLENQEALQ LQVACMQFIN ALVTSPYELD FRIHLRNEFL RSGLKTMLPD
LKEKENDELD IQLKVFDENK EDDLTELSHR LNDIRAEMDD MNEVYHLLYN MLKDTAAENY
FLSILQHFLL IRNDYYIRPQ YYKIIEECVS QIVLHCSGMD PDFKYRQRLD IDLTHLIDSC
VNKAKVEESE QKAAEFSKKF DEEFTARQEA QAELQKRDEK IKELEAEIQQ LRTQAQVLSS
SSGIPGPPPA PPLPGVGPPP PPPAPPLPGG APLPPPPPPL PGMMGIPPPP PPPLLFGGPP
PPPPLGGVPP PPGISLNLPY GMKQKKMYKP EVSMKRINWS KIEPTELSEN CFWLKVKEDK
FENPDLFAKL ALNFATQIKV QKNAEALEEK KTGPTKKKVK ELRILDPKTA QNLSIFLGSY
RMPYEDIRNV ILEVNEDMLS EALIQNLVKH LPEQKILNEL AELKNEYDDL CEPEQFGVVM
SSVKMLQPRL SSILFKLTFE EHVNNIKPSI IAVTLACEEL KKSESFNRLL ELVLLVGNYM
NSGSRNAQSL GFKINFLCKI RDTKSADQKT TLLHFIADIC EEKYRDILKF PEELEHVESA
SKVSAQILKS NLASMEQQIV HLERDIKKFP QAENQHDKFV EKMTAEVEVV IIIFLLTT
//
