ID A0A2R9C930_PANPA Unreviewed; 599 AA.
AC A0A2R9C930;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=PHD finger protein 19 {ECO:0000313|Ensembl:ENSPPAP00000038344.1};
GN Name=PHF19 {ECO:0000313|Ensembl:ENSPPAP00000038344.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000038344.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000038344.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000038344.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Polycomblike family.
CC {ECO:0000256|ARBA:ARBA00008084}.
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DR EMBL; AJFE02119267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02119268; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02119269; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02119270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02119271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02119272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9C930; -.
DR SMR; A0A2R9C930; -.
DR STRING; 9597.ENSPPAP00000038344; -.
DR Ensembl; ENSPPAT00000061247.1; ENSPPAP00000038344.1; ENSPPAG00000041871.1.
DR GeneTree; ENSGT00950000183180; -.
DR Proteomes; UP000240080; Chromosome 9.
DR Bgee; ENSPPAG00000041871; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0035098; C:ESC/E(Z) complex; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035064; F:methylated histone binding; IEA:Ensembl.
DR GO; GO:0045814; P:negative regulation of gene expression, epigenetic; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
DR GO; GO:0019827; P:stem cell population maintenance; IEA:Ensembl.
DR CDD; cd15579; PHD1_PHF19; 1.
DR CDD; cd15581; PHD2_PHF19; 1.
DR CDD; cd20451; Tudor_PHF19; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.90.980.20; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR040477; KDM4-like_Tudor.
DR InterPro; IPR025894; Mtf2_C_dom.
DR InterPro; IPR042017; PHF19_PHD2.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR047400; Tudor_PHF19.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12628:SF6; PHD FINGER PROTEIN 19; 1.
DR PANTHER; PTHR12628; POLYCOMB-LIKE TRANSCRIPTION FACTOR; 1.
DR Pfam; PF14061; Mtf2_C; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF18104; Tudor_2; 1.
DR SMART; SM00249; PHD; 2.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 57..114
FT /note="Tudor"
FT /evidence="ECO:0000259|SMART:SM00333"
FT DOMAIN 117..168
FT /note="Zinc finger PHD-type"
FT /evidence="ECO:0000259|SMART:SM00249"
FT DOMAIN 216..266
FT /note="Zinc finger PHD-type"
FT /evidence="ECO:0000259|SMART:SM00249"
FT REGION 366..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 599 AA; 67646 MW; D2B4EFDCD9AB56E9 CRC64;
MLVLVIRGPY PSAQCQGKLM ENRALDPGTR DSYGATSHLP NKGALAKVKN NFKDLMSKLT
EGQYVLCRWT DGLYYLGKIK RVSSSKQSCL VTFEDNSKYW VLWKDIQHAG VPGEEPKCNI
CLGKTSGPLN EILICGKCGL GYHQQCHIPI AGSADQPLLT PWFCRRCIFA LAVRKGGALK
KGAIARTLQA VKMVLSYQPE ELEWDSPHRT NQQQCYCYCG GPGEWYLRML QCYRCRQWFH
EACTQCLNEP MMFGDRFYLF FCSVCNQGPE YIERLPLRWV DVVHLALYNL GVQSKKKYFD
FEEILAFVNH HWELLQLGKL TSTPVTDRGP HLLNALNSYK SRFLCGKEIK KKKCIFRLRI
RVPPNPPGKL LPDKGLLPNE NSASSELRKR GKSKPGLLPH EFQQQKRRVY RRKRSKFLLE
DAIPSSDFTS AWSTNHHLAS IFDFTLDEIQ SLKSASSGQT FFSDVDSTDA ASTSGSASTS
LSYDSRWTVG SRKRKLAAKA YMPLRAKRWA AELDGRCPSD SSAEGASVPE RPDEGIDSHT
FESISEDDSS LSHLKSSITN YFGAAGRLAC GEKYQVLARR VTPEGKVQYL VEWEGTTPY
//
