ID A0A2R9C9Z4_PANPA Unreviewed; 339 AA.
AC A0A2R9C9Z4;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Glycoprotein VI platelet {ECO:0000313|Ensembl:ENSPPAP00000035194.1};
GN Name=GP6 {ECO:0000313|Ensembl:ENSPPAP00000035194.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000035194.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000035194.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000035194.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJFE02030738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003809941.1; XM_003809893.3.
DR AlphaFoldDB; A0A2R9C9Z4; -.
DR SMR; A0A2R9C9Z4; -.
DR Ensembl; ENSPPAT00000058082.1; ENSPPAP00000035194.1; ENSPPAG00000040421.1.
DR GeneTree; ENSGT01100000263478; -.
DR Proteomes; UP000240080; Chromosome 19.
DR Bgee; ENSPPAG00000040421; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd05751; IgC2_D1_LILR_KIR_like; 1.
DR CDD; cd05711; IgC2_D2_LILR_KIR_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR11738; MHC CLASS I NK CELL RECEPTOR; 1.
DR PANTHER; PTHR11738:SF159; PLATELET GLYCOPROTEIN VI; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..339
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015312333"
FT TRANSMEM 270..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..108
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT DOMAIN 39..95
FT /note="Immunoglobulin subtype 2"
FT /evidence="ECO:0000259|SMART:SM00408"
FT DOMAIN 119..203
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT DOMAIN 125..187
FT /note="Immunoglobulin subtype 2"
FT /evidence="ECO:0000259|SMART:SM00408"
FT REGION 299..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 339 AA; 36906 MW; 9F262122DAB8BB6F CRC64;
MSPSPTALFC LGLCLGRVPA QSGPLPKPSL QALPSSLVPL EKPVTLRCQG PPGVDLYRLE
KLSSSRYQDQ AVLFIPAMKR SLAGRYRCSY QNGSLWSLPS DQLELIATGV FAKPSLSAQP
SPAVSSGGDV TLQCQTRYGF DQFALYKEGD PAPYKNPERW YRASFPIITV TAAHSGTYRC
YSFSSRDPYL WSAPSDPLEL VVTGSSVTPS RLPTEPPSSV AEFSEATAEL TISFTNKVFT
TETSRSITAS PKESDSPAGP ARQYYTKGNL VRICLGAVIL ILLAGFLAED WHSRRKRLRH
RGRAVQRPLP PLPPLPQTRK SHGGQDGGRP DVHSRGLCS
//
