ID A0A2R9CAD2_PANPA Unreviewed; 1455 AA.
AC A0A2R9CAD2;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Plexin C1 {ECO:0000313|Ensembl:ENSPPAP00000037913.1};
GN Name=PLXNC1 {ECO:0000313|Ensembl:ENSPPAP00000037913.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000037913.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000037913.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000037913.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AJFE02057534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02057535; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02057536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02057537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02057538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9597.ENSPPAP00000037913; -.
DR Ensembl; ENSPPAT00000060815.1; ENSPPAP00000037913.1; ENSPPAG00000041664.1.
DR GeneTree; ENSGT01020000230394; -.
DR OMA; QFDGGSC; -.
DR Proteomes; UP000240080; Chromosome 12.
DR Bgee; ENSPPAG00000041664; Expressed in prefrontal cortex and 6 other cell types or tissues.
DR GO; GO:0150053; C:cerebellar climbing fiber to Purkinje cell synapse; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:1905806; P:regulation of synapse pruning; IEA:Ensembl.
DR CDD; cd00102; IPT; 2.
DR CDD; cd12789; RasGAP_plexin_C1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF4; PLEXIN-C1; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01833; TIG; 2.
DR SMART; SM00429; IPT; 2.
DR SMART; SM00423; PSI; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 840..861
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 980..1001
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..347
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
SQ SEQUENCE 1455 AA; 163444 MW; 90D5ACDDEDE29B84 CRC64;
LASFSKLLLP YREGAAGLGG LLLTGWTFDR GACEVRPLGN LSRSSLRNGT EVVSCHPQGS
TAGVVYRAGR NNRWYLAVAA TYVLPEPETA SRCNPAASDH DTAIALKDTE GRSLATQELG
RLKLCEGAGS LHFVDAFLWN GSIYFPYYPY NYTSGAATGW PSMARIAQST EVLFQGQASL
DCGHGHPDGR RLLLSSSLVE ALDVWAGVFS AAAGEGQERR SPTTTALCLF RMSEIQARAK
RVICSWDFRN IWDQPERVQP IASSTLIHSD LTSVYGTVVM NRTVLFLGTG DGQLLKVILG
ENLTSNCPEV IYEIKEETPV FYKLVPDPVK NIYIYLTAGK EVRRIRVANC NKHKSCSECL
TATDPHCGWC HSLQRCTFQG DCVHSENLEN WLDISSGAKK CPKIQIIRSS KEKTTVTMVG
SFSPRHSKCM VKNVDSSREL CQNKSQPNRT CTCSIPTRAT YKDVSVVNVM FSFGSWNLSD
RFNFTNCSSL KECPACVETG CAWCKSARRC IHPFTACDPS DYERNQEQCP VAVEKTSGGG
RPKENKGNRT NQALQVFYIK SIEPQKVSTL GKSNVIVTGA NFTRASNITM ILKGTSTCDK
DVIQVSHVLN DTHMKFSLPS SRKEMKDVCI QFDGGNCSSV GSLSYIALPH CSLIFPATTW
ISGGQNITMM GRNFDVIDNL IISHELKGNI NVSEYCVATY CGFLAPSLKS SKVRTNVTVK
LRVQDTYLDC GTLQYLEDPR FTGYRVESEV DTELEVKIQK ENDNFNISKK DIEITLFHGE
NGQLNCSFEN ITRNQDLTTI LCKIKGIKTA STIANSSKKV RVKLGNLELY VEQESVPSTW
YFLIVLPVLL VIVIFAAVGV TRHKSKELSR KQSQQLELLE SELRKEIRDG FAELQMDKLD
VVDSFGTVPF LDYKHFALRT FFPESGGFTH IFTEDMHNRD ANDKNESLTA LDALICNKSF
LVTVIHTLEK QKNFSVKDRC LFASFLTIAL QTKLVYLTSI LEVLTRDLME QCSNMQPKLM
LRRTESVVEK LLTNWMSVCL SGFLRETVGE PFYLLVTTLN QKINKGPVDV ITCKALYTLN
EDWLLWQVPE FSTVALNVVF EKIPENESAD VCRNISVNVL DCDTIGQAKE KIFQAFLSKN
GSPYGLQLNE IGLELQVGTR QKELLDIDSS SVILEDGITK LNTIGHYEIS NGSTIKVFKK
IANFTSDVEY SDDHCHLILP DSEAFQDVQG KRHRGKHKFK VKEMYLTKLL STKVAIHSVL
EKLFRSIWSL PNSRAPFAIK YFFDFLDAQA ENKKITDPDV VHIWKTNSLP LRFWVNILKN
PQFVFDIKKT PHIDGCLSVI AQAFMDAFSL TEQQLGKEAP TNKLLYAKDI PTYKEEVKSY
YKAIRDLPPL SSSEMEEFLT QESKVSLESR NKLIFGYFTS FQNLSTKRER GLEEAQKQLL
HVKVLFDEKK KCKWM
//
