ID A0A2R9CD50_PANPA Unreviewed; 2397 AA.
AC A0A2R9CD50;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Spectrin beta chain {ECO:0000256|PIRNR:PIRNR002297};
GN Name=SPTBN4 {ECO:0000313|Ensembl:ENSPPAP00000039871.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000039871.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000039871.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000039871.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826, ECO:0000256|PIRNR:PIRNR002297}.
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DR EMBL; AJFE02039786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02039787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02039788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02039789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02039790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02039791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02039792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02039793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02039794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02039795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPPAT00000062783.1; ENSPPAP00000039871.1; ENSPPAG00000042534.1.
DR GeneTree; ENSGT00940000156343; -.
DR Proteomes; UP000240080; Chromosome 19.
DR Bgee; ENSPPAG00000042534; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0008091; C:spectrin; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:UniProtKB-UniRule.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-UniRule.
DR CDD; cd21322; CH_SPTBN4_rpt2; 1.
DR CDD; cd10571; PH_beta_spectrin; 1.
DR CDD; cd00176; SPEC; 6.
DR Gene3D; 1.20.58.60; -; 11.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR016343; Spectrin_bsu.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF232; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 4; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF00435; Spectrin; 14.
DR PIRSF; PIRSF002297; Spectrin_beta_subunit; 2.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00033; CH; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00150; SPEC; 15.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 13.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467,
KW ECO:0000256|PIRNR:PIRNR002297};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR002297}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR002297};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR002297};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..103
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 118..223
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 2251..2360
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 615..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1371..1395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2027..2266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2366..2397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 402..436
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1288..1315
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1501..1528
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2065..2151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2201..2227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2397 AA; 270698 MW; AB8E78104180F130 CRC64;
QKKTFTKWVN SHLARVGCHI GDLYVDLRDG FVLTRLLEVL SGEQLPRPTR GRMRIHSLEN
VDKALQFLKE QRVHLENVGS HDIVDGNHRL TLGLVWTIIL RFQIQVIKIE TEDNRETRSA
KDALLLWCQM KTAGYPEVNI QNFTTSWRDG LAFNALIHRH RPDLVDFSKL TKSNANYNLQ
RAFRTAEQHL GLARLLDPED VNMEAPDEKS IITYVVSFYH YFSKMKALAV EGKRIGKVLD
QVLEVGKIIE RYEELAAELL AWIHRTVGLI SNQKFANSLS GVQQQLQAFT AYCTLEKPVK
FQEKGNLEVL LFSIQSKLRA CNRRLFVPRE GCGIWDIDKA WGELEKAEHE REAALRAELI
RQEKLELLAQ RFDHKVAMRE SWLNENQRLV SQDNFGYELP AVEAAMKKHE AIEADIAAYE
ERVQGVAELA QALAAEGYYD IRRVAAQRDS VLRQWALLTG LVGARRTRLE QNLALQKVFQ
EMVYMVDWME EMQAQLLSRE CGQHLVEADD LLQKHGLLEG DIAAQSERVE ALNAAALRFS
QLQGYQPCDP QVICNRVNHV HGCLAELQEQ AARRRAELEA SRSLWALLQE LEEAESWARD
KERLLEAAGG GGAAGAAGAA GTAGGAHDLS STARPPRPSN KILRGRAWAG GGVAAAGPAV
HRAPVGLAER AASARRRWQR LEEAAARRER RLQEARALHQ FGADLDGLLD WLRDAYRLAA
AGDFGHDEAS SRRLARQHRA LTGEVEAHRG PVSGLRRHGA GPLVVALQVR VVEAEQLFAE
VTEVAALRRQ WLRDALAVYR MFGEVHACEL WIGEKEQWLL SMRVPDSLDD VEVVQHRFES
LDQEMNSLMG RVLDVNRTVQ ELVEGGHPSS DEVRSCQDHL NSRWNRIVEL VEQRKEEMSA
VLLVENHVLE VAEVRAQVRX XXXXXXVAAA GRLQRFLHDL DAFLDWLVRA QEAAGGSEGP
LPNSLEEADA LLARHAALKE EVDQREEDYA RIVAASEALL AADGAELGPG LALDEWLPHL
ELGWHKLLGL WEARREALVQ AHIYQLFLRD LRQALVVLRN QEMALSGAEL PGTVESVEEA
LKQHRDFLTT MELSQQKMQV AVQAAEGLLR QGNIYGEQAQ EAVTRLLEKN QENQLRAQQW
MQKLHDQLEL QHFLRDCHEL DGWIHEKMLM ARDGTREDSH KLHKRWLRHQ AFMAELAQNK
EWLEKIEREG QQLMQEKPEL AASVRKKLGE IRQCWAELES TTQAKARQLF EASKADQLVQ
SFAELDKKLL HMESQLQDVD PGGDLATVNS QLKKLQSMES QVEEWYREVG ELQAQTAALP
LEPASKELVG ERQNAVGERL VRLLEPLQER RRLLLASKEL HQVAHDLDDE LVRPAQGPGG
LGTPPLHPHP LTSCPQGLRR EIQAHGPRLE EVLERAGALA SLRSPEAEAV RRGLEQLQSA
WAGLREAAER RQQVLDAAFQ VEQYYFDVAE VEAWLGEQEL LMMSEDKGKD EQSTLQLLKK
HLQLEQGVEN YEESIAQLSR QCRALLEMGA PGQQISRRQS QVDRLYVALK ELGEERRVAL
EQQYWLYQLS RQVSELEHWI AEKEVVAGSP ELGQDFEHVS VLQEKFSEFA SETGTAGRER
LAAVNQMVDE LIECGHTAAA TMAEWKDGLN EAWAELLELM GTRAQLLAAS RELHKFFSDA
RELQGQIEEK RRRLPRLTTP PEPRPSASSM QRTLRAFEHD LQLLVSQVRQ LQEGAAQLRT
VYAGEHAEAI ASREQEVLQG WKELLSACED ARLHVSSTAD ALRFHSQVRD LLSWMDGIAS
QIGAADKPRD VSSVEVLMNY HQGLKTELEA RVPELTTCQE LGRSLLLNKS AMADEIQAQL
DKLGTRKEEV SEKWDRHWEW LQQMLEVHQF AQEAVVADAW LTAQEPLLQS RELGSSVDEV
EQLIRRHEAF RKAAAAWEER FSSLRRLTTI EKIKAEQSKQ PPTPLLGRKF FGDPTELAAK
AAPLLRPGGY ERGLEPLARR ASDTLSAEVR TRVGYVRQEL KPERLQPRID RLPEIPGRVE
PAALPAAPED AAETPVTPAA AEQVRPRPER QESADRAEEL PRRRRPERQE SVDQSEEAAR
RRRPERQESA EHEAAHSLTL GRYEQMERRR ERRERRLERQ ESSEQEMPIR GDLVKGKATL
ADIVEQLQEK EAGPGLPAGP SLPQPRELPP GRLPNGLELP ERTPRPDRPR GAGPAKPRRR
EGGEGGGSRR SRSAPAQGGS APAPPPPPTH TVQHEGFLLR KRELDANRKS SNRSWVSLYC
VLSKGELGFY KDSKGPASGS THGGEPLLSL HKATSEVASD YKKKKHVFKL QTQDGSEFLL
QAKDEEEMNG WLEAVASSVA EHAEIARWGQ TLPTTSSTDE GNPKRESGDR RASGRRK
//
