ID A0A2R9CDN7_PANPA Unreviewed; 383 AA.
AC A0A2R9CDN7;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=WD repeat-containing protein 55 {ECO:0000256|ARBA:ARBA00021188, ECO:0000256|PIRNR:PIRNR038169};
GN Name=WDR55 {ECO:0000313|Ensembl:ENSPPAP00000039999.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000039999.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000039999.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000039999.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Nucleolar protein that acts as a modulator of rRNA synthesis.
CC Plays a central role during organogenesis.
CC {ECO:0000256|ARBA:ARBA00025196, ECO:0000256|PIRNR:PIRNR038169}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus, nucleolus {ECO:0000256|PIRNR:PIRNR038169}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR55 family.
CC {ECO:0000256|ARBA:ARBA00007625, ECO:0000256|PIRNR:PIRNR038169}.
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DR EMBL; AJFE02102667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02102668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008952790.1; XM_008954542.2.
DR RefSeq; XP_008952791.1; XM_008954543.2.
DR AlphaFoldDB; A0A2R9CDN7; -.
DR STRING; 9597.ENSPPAP00000039999; -.
DR Ensembl; ENSPPAT00000062912.1; ENSPPAP00000039999.1; ENSPPAG00000042662.1.
DR GeneID; 100971199; -.
DR KEGG; pps:100971199; -.
DR CTD; 54853; -.
DR GeneTree; ENSGT00940000153727; -.
DR OMA; MFENLCT; -.
DR OrthoDB; 153323at2759; -.
DR Proteomes; UP000240080; Chromosome 5.
DR Bgee; ENSPPAG00000042662; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR017422; WDR55.
DR PANTHER; PTHR44019; WD REPEAT-CONTAINING PROTEIN 55; 1.
DR PANTHER; PTHR44019:SF20; WD REPEAT-CONTAINING PROTEIN 55; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 1.
DR PIRSF; PIRSF038169; WD_repeat_p55; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|PIRNR:PIRNR038169};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW rRNA processing {ECO:0000256|PIRNR:PIRNR038169};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PIRNR:PIRNR038169}.
FT DOMAIN 45..124
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 80..121
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 298..332
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 383 AA; 42109 MW; E637DDCAD2F45C78 CRC64;
MDRTCEERPA EDGSDEEDPD SMEAPTRIRD TPEDIVLEAP ASGLAFHPAR DLLAAGDVDG
DVFVFSYSCQ EGETKELWSS GHHLKACRAV AFSEDGQKLI TVSKDKAIHV LDVEQGQLER
RVSKAHGAPI NSLLLVDENV LATGDDTGGI RLWDQRKEGP LMDMRQHEEY IADMALDPAK
KLLLTASGDG CLGVFNIKRR RFELLSEPQS GDLTSVTLMK WGKKVACGSS EGTIYLFNWN
GFGATSDRFA LRAESIDCMV PVTESLLCTG STDGVIRAVN ILPNRVVGSV GQHTGEPVEE
LALSHCGRFL ASSGHDQRLK FWDMAQLRAV VVDDYRRRKK KGGPLRALSS KTWSTDDFFA
GLREEGEDSM AQEEKEETGD DSD
//
